A novel immune regulation mechanism by Ca-independent PLA2 and its contribution to neurodegenerative diseases

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390117
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: St.Marianna University School of Medicine
• Principal Investigator: SEINO Ken-Ichiro St.Marianna University School of Medicine, 遺伝子病制御研究所, 教授 (20312845)
• Research Collaborator: WADA Haruka 北海道大学, 遺伝子病制御研究所, 助教 (70392181) ; KOJO Satoshi 北海道大学, 遺伝子病制御研究所, 助教 (70360542)
• Project Period (FY): 2008 – 2010
• Keywords: 疾患モデル動物 / NKT細胞 / INAD

Research Abstract

We have investigated the mutant mice bearing a point mutation in Ca-independent PLA2 (iPLA2・、Pla2g6) . They showed a progressive paralysis in their lower limbs since several weeks after the birth. The mutant mice were realized as model mice of human infantile neuroaxonal dystrophy. The mice also showed some immune abnormality such as increase of NKT cell population. We can use the mutant mice for further investigating the disease mechanism and developing new therapeutic strategies.

Research Products

• [Journal Article] Establishment of an improved mouse model for infantile neuroaxonal dystrophy bearing a point mutation in Pla2g6 which shows early disease onset. (2009)
  • Author(s): Wada H, Yasuda T, Miura I, Watabe K, Sawa C, Kamijuku H, Kojo S, Taniguchi M, Nishino I, Wakana S, Yoshida H, Seino K.
  • Journal Title: Am J Pathol 175 Pages: 2257-63
  • Peer Reviewed
• [Presentation] Establishment of a mouse mutant bearing a point mutation in Pla2g6 which show early onset of neuroaxonal dystrophy. (2009)
  • Author(s): Wada H, Yasuda T, Sawa C, Kamijuku H, Watabe K, Yoshida H, Seino K.
  • Organizer: Phospholipase A_2 and Lipid Mediators PLM2009
  • Year and Date: 2009-05-25
• [Remarks] ホームプージ等