2010 Fiscal Year Final Research Report
Genome sequencing of the Plasmodium vivax-related monkey malaria parasite, P. cynomolgi, by the massive sequencing system
| Project/Area Number |
20390120
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Parasitology (including Sanitary zoology)
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
TANABE Kazuyuki Osaka University, 微生物病研究所, 招へい教授 (40047410)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YASUNAGA Teruo 大阪大学, 微生物病研究所, 教授 (20260630)
KAWAI Satoru 獨協医科大学, 医学部, 准教授 (70275733)
HAYAKAWA Toshiyuki 京都大学, 霊長類研究所, 特任助教 (80418681)
SAWAI Hiromi 東京大学, 大学院・医学研究科, 特任研究員 (60377124)
TOYAMA Tomoko 大阪大学, 微生物病研究所, 特任研究員 (40456934)
|
|---|
| Research Collaborator |
TACHIBANA Shin-Ichiro 大阪大学, 微生物病研究所, 特任研究員 (90414630)
NAKAMURA Shota 大阪大学, 微生物病研究所, 特任助教 (90432434)
GOTO Naohisa 大阪大学, 微生物病研究所, 助教 (60448157)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | マラリア / 三日熱マラリア原虫 / サルマラリア原虫 / ゲノム / 進化 / 寄生 |
|---|
| Research Abstract |
Plasmodium vivax infects only humans, although it is closely related to Old World monkey malaria parasites. In order to reveal genetic backgrounds of host switch and human infection of P. vivax, genome sequencing of P. cynomolgi and comparative genomic analyses were performed. Results revealed that about 10% of genes of the genomes are species-specific and belong to multigene families. Intriguingly, the number of genes in the DBP and RBP families, which encode parasite's ligands for the recognition of host erythrocytes, differed between P. vivax and related monkey malaria parasites.
|
-
-
[Journal Article] Plasmodium falciparum accompanied the human expansion out of Africa.2010
Author(s)
K.Tanabe, T.Mita, T.Jombart, A.Eriksson, S.Horibe, N.Palacpac, L.Ranford-Cartwright, H.Sawai, N.Sakihama, H.Ohmae, M.Nakamura, M.U.Ferreira, A.A.Escalante, F.Prugnolle, A.Bjorkman, A.Farnert, A.Kaneko, T.Horii, A.Manica, H.Kishino, F.Balloux
-
Journal Title
Peer Reviewed
-
[Journal Article] Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites.2010
Author(s)
H.Sawai, H.Otani, N.Arisue, N.Palacpac, L.de Oliveira Martins, S.Pathirana, S.Handunnetti, S.Kawai, H.Kishino, T.Horii, K.Tanabe
-
Journal Title
BMC Evol.Biol. 10
Pages: 52
Peer Reviewed
-
[Journal Article] Evidence for the transmission of Plasmodium vivax in the Republic of Congo, West Central Africa.2009
Author(s)
R.Culleton, M.Ndounga, F.Y.Zeyrek, C.Coban, P.N.Casimiro, S.Takeo, T.Tsuboi, A.Yadava, R.Carter, K.Tanabe
-
Journal Title
J.Infect.Dis. 200(9)
Pages: 1465-1469
Peer Reviewed
-
-
[Journal Article] Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing.2008
Author(s)
R.Culleton, T.Mita, M.Ndounga, H.Unger, P.Cravo, G.Paganotti, N.Takahashi, A.Kaneko, H.Eto, H.Tinto, C.Karema, U.D'Alessandro, V.do Rosario, T.Kobayakawa, F.Ntoumi, R.Carter, K.Tanabe
-
Journal Title
Peer Reviewed
-
-
-
[Presentation] Genome sequencing of the P. vivax-related monkey malaria parasite, P. cynomolgi and the comparative genomic analysis.2010
Author(s)
S. Tachibana, S. Kawai, N. Goto, S. Nakamura, N.Arisue, Y. Katakai, H.Honma, N.Palacpac, H.Sawai, T. Tougan, K. Kita, Y. Yasutomi, T. Horii, T. Yasunaga, K. Tanabe
Organizer
The 10^<th> Awaji International Forum on Infection and Immunity.
Place of Presentation
Hyogo, Japan
Year and Date
2010-09-09
-
-
[Presentation] 次世代シーケンサーによる三日熱マラリア原虫近縁サルマラリア原虫P. cynomolgiのゲノム解読2010
Author(s)
橘真一郎, 川合覚, 後藤直久, 中村昇太, 片貝祐子, 澤井裕美, 東岸任弘, 北潔, 保富康宏, 堀井俊宏, 安永照雄, 田邉和裄
Organizer
第79回日本寄生虫学会大会
Place of Presentation
北海道
Year and Date
2010-05-20
-
-
-
-
