Analysis of multi-functions of staphylococcal enterotoxin family and their significance

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20390122
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: Hirosaki University
• Principal Investigator: NAKANE Akio Hirosaki University, 大学院・医学研究科, 教授 (30164239)
• Project Period (FY): 2008 – 2010
• Keywords: ブドウ球菌エンテロトキシン / スーパー抗原 / 嘔吐活性 / 感染 / IL-17 / TSST-1 / SEA

Research Abstract

黄色ブドウ球菌が産生するエンテロトキシン(SE)は現在21種類報告おり、多彩なSEは黄色ブドウ球菌の生き残りにとって必須な分子群と考えられる。本申請者らのこれまでの研究で、SEは感染において炎症誘導だけではなく、複数の機序によって感染成立に関与している可能性が示唆される。そこで、本研究ではその機序を解明する。また、まだその分子機序が明らかではないSEAの嘔吐誘導活性の分子機序についても解明する。
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Research Products

• [Journal Article] High affinity of interaction between superantigen and TCRVβ molecules induces a high level and prolonged expansion of superantigen-reactive CD4^+ T cells (2010)
  • Author(s): Omoe K, Nunomura W, Kato H, Li Z-J, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu D-L, Nakane A, Kiyono H, Takakura Y, Shinagawa K, Uchiyama T, Imanishi KI.
  • Journal Title: J Biol Chem 285 Pages: 30427-30435
  • Peer Reviewed
• [Journal Article] Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mice immunized with the fibronectin-binding domain of clumping factor (2010)
  • Author(s): Narita K, Hu D-L, Mori F, Wakabayashi K, Iwakura Y, Nakane A.
  • Journal Title: Infect Immun 78 Pages: 4234-4242
  • Peer Reviewed
• [Journal Article] c-di-GMP as vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection (2009)
  • Author(s): Hu D-L, Narita K, Hyodo M, Hayakawa Y, Nakane A, Karaolis DKRInfect Immun
  • Journal Title: Vaccine 27 Pages: 4867-4873
  • Peer Reviewed
• [Journal Article] Immunization with a nontoxic mutant of staphylococcal enterotoxin A, SEA D227A, protects against enterotoxin-inducedemesis in house musk shrews (2009)
  • Author(s): Hu D-L, Omoe K, Sashinami H, Shinagawa K, Nakane A.
  • Journal Title: J Infect Dis 199 Pages: 302-310
  • Peer Reviewed
• [Journal Article] Comparative prevalence of superantigenic toxin genes in methicillin-resistant and methicillin- susceptible Staphylococcus aureus isolates (2008)
  • Author(s): Hu D-L, Omoe K, Inoue F, Kasai T, Yasujima M, Shinagawa K, Nakane A.
  • Journal Title: J Med Microbiol 57(9) Pages: 1106-1112
  • Peer Reviewed
• [Presentation] The role of IL-17A in the cell-mediated immunity induced by an immunization with clumping factor A against Staphylococcus aureus infection (2010)
  • Author(s): Narita K, Hu D-L, Nakane A.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe International Exhibition Hall, Kobe, Japan
  • Year and Date: 2010-08-25
• [Presentation] C-di-GMP as a vaccine adjuvant enhances protection against Staphylococcus aureus infection (2010)
  • Author(s): 胡東良、成田浩司、中根明夫
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜パシフィコ(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] A nontoxic mutant staphylococcal enterotoxin A protects against enterotoxin-induced emesis (2009)
  • Author(s): 胡東良、重茂克彦、差波拓志、品川邦汎、中根明夫
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-03-12
• [Presentation] Staphylococcal enterotoxin A induces emesis through increasing serotonin release in intestine and endogenous cannabinoid system protects against emetic response (2008)
  • Author(s): Hu D-L, Omoe K, Shinagawa K, Nakane A.
  • Organizer: 13^<th> International Symposium on Staphylococci and Staphylococcal Infections
  • Place of Presentation: Cairns Convention Centre, Cairns, Australia
  • Year and Date: 2008-09-07
• [Remarks] ホームページ情報
  • URL: http://www.bact.hirosaki-u.ac.jp/