2010 Fiscal Year Final Research Report
Analysis of efficacy of a vaccine inducing confined avirulent virus replication against immunodeficiency virus infection
| Project/Area Number |
20390131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases (2010)
The University of Tokyo (2008-2009) |
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Principal Investigator |
MATANO Tetsuro National Institute of Infectious Diseases, エイズ研究センター, センター長 (00270653)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ウイルス / 感染症 / ワクチン2HIV / エイズ / 細胞傷害性Tリンパ球 |
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| Research Abstract |
We analyzed the effect of a prophylactic AIDS vaccine inducing confined replication of an avirulent virus on cytotoxic T lymphocyte (CTL) responses in macaques after simian immunodeficiency virus (SIV) challenge. Our analysis revealed that prophylactic vaccination results in dominant induction of vaccine antigen-specific CTL responses post-viral exposure but delays SIV non-vaccine antigen-specific CTL responses. These results imply a significant influence of prophylactic vaccination on CTL immunodominance post-viral exposure, providing insights into antigen design in development of a CTL-inducing AIDS vaccine.
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