2010 Fiscal Year Final Research Report
Novel host factors in HIV-1 replication
| Project/Area Number |
20390132
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
SHIODA Tatsuo Osaka University, 微生物病研究所, 教授 (00187329)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子 / 感染抵抗性 / ゲノム / 一塩基多型 / HIV感染症 / DNAチップ |
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| Research Abstract |
From the Genome-Wide Association Study of human genetic polymorphisms of HIV-1-infected and non-HIV-1-infected individuals, we were able to identify several single nucleotide polymorphisms which are potentially involved in natural HIV-1 resistance. Furthermore, we have shown that the anti-retroviral factor TRIM5 ・binds to TAB2, which also binds to a signal transducer TAK1. These host factors involved in HIV-1 replication may be potential targets for developing novel anti-HIV-1 therapy.
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[Journal Article] HIV-2 Capsids Distinguish High and Low Virus Load Patients in a West African Community Cohort.2010
Author(s)
Onyango CO, Leligdowicz A, Yokoyama T, Sato H, Song H, Nakayama EE, Shioda T, Silva T, Townend J, Jaye A, Whittle H, Towland-Jones S, Cotton T.
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Journal Title
Vaccine. 28S2
Pages: B60-B67
Peer Reviewed
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[Journal Article] TIT1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand.2010
Author(s)
Wichukchinda N, Nakajima T, Saipradit N, NakayamaEE, Ohtani H, Tojanawiwat A, Pathipvanich P, Ariyoshi T, Sawanpanyalert P, Shioda T, Timura A.
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Journal Title
Peer Reviewed
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[Journal Article] Impact of novel TTIT5alpha variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection.2009
Author(s)
Nakajima T, Nakayama EE, Taur G, Terunuma H, Timaya JI, Ohtani H, Tehra N, Shioda T, Timura A.
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Journal Title
AIDS 23(16)
Pages: 2091-2100
Peer Reviewed
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[Journal Article] Comparison between Sendai virus and Adenovirus vectors to transduce HIV-1 genes into human dendritic cells.2008
Author(s)
Hosoya N, Tiura T, Tawana-Tachikawa A, Toibuchi T, Shioda T, Odawara T, Nakamura T, Titamura Y, Tano T, Tato A, Hasegawa T, Nagai Y, Iwamoto A.
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Journal Title
J Ted Virol. 80
Pages: 373-382
Peer Reviewed
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