2010 Fiscal Year Final Research Report
Tracking the intracellular dynamics of HIV-1 proteins
| Project/Area Number |
20390136
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
RYO Akihide National Institute of Infectious Diseases, 医学研究科, 教授 (20363814)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Naoki 国立感染症研究所, エイズ研究センター, センター長 (00094053)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ヒト免疫不全ウイルス / エイズ / 宿主因子 / 細胞内輸送 |
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| Research Abstract |
Human immunodeficiency virus type 1 (HIV-1) utilizes the macromolecular machinery of the infected host cell to produce progeny virus. We have identified suppressor of cytokine signaling 1 (SOCS1) as a host factor that positively regulates the intracellular trafficking and stability of HIV-1 Gag. SOCS1 can directly bind to Gag and enhance its stability and trafficking, resulting in the efficient production of HIV-1 particles. We found also that SOCS1 can enhance the ubiqtuitintion of Gag and facilitate its interaction with microtubule network. These findings will be useful for developing a new anti-HIV therapy.
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Journal Title
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