2010 Fiscal Year Final Research Report
Epstein-Barr virus lytic replication and host factors supporting its replication
| Project/Area Number |
20390137
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
TSURUMI Tatsuya Aichi Cancer Center Research Institute, 部長 (90172072)
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| Co-Investigator(Renkei-kenkyūsha) |
KANDA Teru 愛知県がんセンター(研究所), 室長 (50333472)
ISOMURA Hiroki 愛知県がんセンター(研究所), 室長 (20294415)
MURATA Takayuki 愛知県がんセンター(研究所), 研究員 (30470165)
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| Project Period (FY) |
2008 – 2010
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| Keywords | EBV / 複製 / 転写 / 溶解感染 / 構造 / 機能 |
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| Research Abstract |
Epstein-Barr virus (EBV) is a DNA tumor virus、possessing two alternative life cycle ; latent and lytic. EBV genome replication is occurred in nuclei of the infected cells. In this study we have revealed that TORC2 (Transducer of Regulated CREB 2) and HIF-2αis involved in the reactivation from the latency. Furthermore, We have showed the three dimensional structure of BMRF1, one of EBV replication proteins, and its relationship with its functions on DNA binding, polymerase processivity, and lytic replication.
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Research Products
(56 results)
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[Journal Article] Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication.2010
Author(s)
Sato Y, Shirata N, Murata T, Nakasu S, Kudoh A, Iwahori S, Nakayama S, Chiba S, Isomura H, Kanda T, Tsurumi T.
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Journal Title
Cell Cycle 9
Pages: 807-814
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[Journal Article] ORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein.2009
Author(s)
Murata T, Sato Y, Nakayama S, Kudoh A, Iwahori S, Isomura HH, Tajima M, Hishiki T, Ohshima T, Hijikata M, Shimotohno K Tsurumi T
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Journal Title
J Biol Chem. 284
Pages: 8033-8041
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