2010 Fiscal Year Final Research Report
Roles of cytokines and TLRs in lymphocyte activation and differentiation
| Project/Area Number |
20390141
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | University of Toyama |
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Principal Investigator |
TAKATSU Kiyoshi University of Toyama, 大学院・医学薬学研究部(医学), 教授 (10107055)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Yoshinori 富山大学, 大学院・医学薬学研究部(医学), 准教授 (30431761)
IKUTANI Masashi 富山大学, 大学院・医学薬学研究部(医学), 助教 (40513718)
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| Project Period (FY) |
2008 – 2010
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| Keywords | リンパ球 / IL-5 / TLR / 抗原交叉提示 |
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| Research Abstract |
To investigate IL-5-producing cells in the peripheral tissues, we succeeded to generate IL-5/GFP knock-in mice. IL-5/GFP^+ cells were distributed mainly in the lung and intestinal tissues and they were CD3^- c-kit^- cells but not CD3^+ T cells. We also analyzed RP105 signals in B cell activation and found that RP105 was required for TLR4-dependent plasma cell differentiation and IgM production. Finally, we demonstrated that an interferon-inducible gene Iigp1 had a crucial role in Th1-dependent antigen cross-presentation.
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