2010 Fiscal Year Final Research Report
Determination and molecular and genetic marker in the allergy produced by RS virus infection and its prevention
| Project/Area Number |
20390170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKAMURA Hiroyuki Kanazawa University, 医学系, 教授 (30231476)
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| Co-Investigator(Kenkyū-buntansha) |
HITOMI Yoshiaki 金沢大学, 医学系, 准教授 (70231545)
KAMBAYASHI Yasuhiro 金沢大学, 医学系, 講師 (20345630)
HIBINO Yuri 金沢大学, 医学系, 助教 (40362008)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アレルギー / RSウイルス / ワクチン / S糖タンパク遺伝子 / CpGモチーフ / 喘息 / 予防 / Th2サイトカイン |
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| Research Abstract |
This study aimed to clarify the involvement of RS virus in allergic diseases and develop preventive methods by determining the molecular and genetic marker in it. Animal experiments and molecular epidemiology determined Th2 cytokines, LR4 and CD4 as the markers. DNA vaccine containing S glycoprotein gene was found to lead to the inactivation of the markers, subsequently resulting in the efficient preventive agents.
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Research Products
(50 results)
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[Journal Article] JAST study group : Difference in early prediction of antipsychotic non-response between risperidone and olanzapine in the treatment of acute-phase schizophrenia.2011
Author(s)
Hatta K, Otachi T, Sudo Y, Hayakawa T, Ashizawa Y, Takebayashi H, Hayashi N, Hamakawa H, Ito S, Nakase R, Usui C, Nakamura H, Hirata T, Sawa Y
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Journal Title
Schizophr Res. 128
Pages: 127-135
Peer Reviewed
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[Journal Article] C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population.2010
Author(s)
Sauriasari R, Sakano N, Wang DH, Takaki J, Takemoto K, Wang B, Sugiyama H, Sato Y, Takigawa T, Takahashi N, Kanbara S, Hitomi Y, Nakamura H, Ogino K
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Journal Title
Hypertens Res. 33
Pages: 1129-1136
Peer Reviewed
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[Journal Article] A prospective naturalistic multicentre study of intravenous medications in behavioural emergencies : haloperidol versus flunitrazepam.2010
Author(s)
Hatta K, Nakamura M, Yoshida K, Hamakawa H, Wakejima T, Nishimura T, Furuta K, Kawabata T, Hirata T, Usui C, Nakamura H, Sawa Y
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Journal Title
Psychiatry Res. 178(1)
Pages: 182-185
Peer Reviewed
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[Journal Article] Nationwide Cross-Sectional Population-Based Study on the Prevalences of Asthma and Asthma Symptoms among Japanese Adults.2010
Author(s)
Fukutomi Y, Nakamura H, Kobayashi F, Taniguchi M, Konno S, Nishimura M, Kawagishi Y, Watanabe J, Komase Y, Akamatsu Y, Okada C, Tanimoto Y, Takahashi K, Kimura T, Eboshida A,Hirota R, Ikei J, Odajima H, Nakagawa T, Akasawa A, Akiyama K
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Journal Title
Int Arch Allergy Immunol. 153(3)
Pages: 280-287
Peer Reviewed
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[Journal Article] Effectiveness of second-generation antipsychotics with acute-phase schizophrenia.2009
Author(s)
Hatta K, Sato K, Hamakawa H, Takebayashi H, Kimura N, Ochi S, Sudo Y, Asukai N, Nakamura H, Usui C, Kawabata T, Hirata T, Sawa Y
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Journal Title
Schizophr Res. 113
Pages: 49-55
Peer Reviewed
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[Journal Article] Olanzapine orally disintegrating tablet vs.risperidone oral solution in the treatment of acutely agitated psychotic patients.2008
Author(s)
Hatta K, Kawabata T, Yoshida K, Hamakawa H, Wakejima T, Furuta K, Nakamura M, Hirata T, Usui C, Nakamura H, Sawa Y
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Journal Title
Gen Hosp Psychiatry. 30(4)
Pages: 367-371
Peer Reviewed
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[Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis.
Author(s)
Tanak T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata S, Sugimoto S, Hatta K, Eboshida A, Konoshita T, Nakamura H
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Journal Title
Peer Reviewed
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[Journal Article] Japanese version of the 2010 American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and the Fibromyalgia Symptom Scale.
Author(s)
Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Ito K, Yamano Y, Nakamura H, Nakajima T, Nishioka K
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Journal Title
Modern Rheumatology in press
Peer Reviewed
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[Journal Article] Time trend in the prevalence of adult asthma in Japan : Findings from population-based surveys in Fujieda City in 1985, 1999, and 2006
Author(s)
Fukutomi Y, Taniguchi M, Watanabe J, Nakamura H, Komase Y, Ohta K, Akasawa A, Nakagawa T, Miyamoto T, Akiyama K
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Journal Title
Peer Reviewed
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