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2010 Fiscal Year Final Research Report

The relation between CYP19 haplotypes and breast cancer risk in Japanese women

Research Project

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Project/Area Number 20390179
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionAichi Prefectural Institute of Public Health

Principal Investigator

HIROSE Kaoru  Aichi Prefectural Institute of Public Health, 企画情報部・健康科学情報, 室長 (00393124)

Co-Investigator(Renkei-kenkyūsha) MATSUO Keitaro  愛知県がんセンター研究所, 疫学・予防部, 室長 (80393122)
Project Period (FY) 2008 – 2010
Keywords乳がん / ハプロタイプ / エストロゲン
Research Abstract

Incidence and death rates of breast cancer in Japan have increased markedly in recently years, especially among postmenopausal women. Many gene polymorphisms of enzymes potentially related to carcinogenesis have been examined for breast cancer risk. Aromatase is one of the key enzymes in estrogen biosynthesis and encoded by CYP19A1. To evaluate impact of CYP19A1 haplotypes on breast cancer risk, we conducted a case-control study. Some haplotyeps in CYP19A1 would influence sex hormones levels, thus suggesting potential importance of CYP19A1 haplotypes on breast cancer risk.

  • Research Products

    (19 results)

All 2011 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (11 results)

  • [Journal Article] Association between vitamin D and calcium intake and breast cancerriskaccording tomenopausal status and receptor status in Japan.2010

    • Author(s)
      Kawase T., Matsuo K., Suzuki T., Hirose K., Hosono S., Watanabe M., Inagaki M., Iwata H., TanakaH.,Tajima K.
    • Journal Title

      Cancer Sci. 101(5)

      Pages: 1234-1240

    • Peer Reviewed
  • [Journal Article] HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.2010

    • Author(s)
      Hosono S., Kawase T., Matsuo K., Watanabe M., Kajiyama H., Hirose K., Suzuki T., Kidokoro K., Ito H., Nakanishi T., Yatabe Y., Hamajima N., Kikkawa F., Tajima K.,Tanaka H.
    • Journal Title

      J Epidemiology. 20(4)

      Pages: 295-301

    • Peer Reviewed
  • [Journal Article] Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women.2010

    • Author(s)
      Hosono S., Matsuo K., Kajiyama H., Hirose K., Suzuki T., Kawase T., Kidokoro K., NakanishiT.,Hamajima N., Kikkawa F., Tajima K., Tnanaka H.
    • Journal Title

      Eur J Clin Nut. 64(4)

      Pages: 400-409

    • Peer Reviewed
  • [Journal Article] Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women.2009

    • Author(s)
      KidokoroK.,Ino K.,HiroseK.,Kajiyama H., Hosono S., Suzuki T.,KawaseT., Hiraki A., Hamajima N., Tanaka H., Tajima K., Kikkawa F., Matsuo K.
    • Journal Title

      J Hum Genetics 54

      Pages: 78-85

    • Peer Reviewed
  • [Journal Article] Effect of soybean on breast cancer according to receptor status : a case-control study in Japan.2008

    • Author(s)
      Suzuki T., MatsuoK.,Tsunoda N.,Hirose K., Hiraki A., Kawase T., Yamashita T., Iwata H., Tanaka H., Tajima K.
    • Journal Title

      Int J Cancer 123(7)

      Pages: 1674-1680

    • Peer Reviewed
  • [Journal Article] Reduced risk of endometrial cancer from alcohol drinking in Japan.2008

    • Author(s)
      Hosono S., Matsuo K., Kajiyama H., HiorseK., SuzukiT., Hiraki A.,Kawase T., Kidokoro K., Nakanishi T., Hamajima N., Kikkawa F., Tajima K., Tanaka H.
    • Journal Title

      Cancer Sci 99

      Pages: 1195-1201

    • Peer Reviewed
  • [Journal Article] Tajima K. Soy consumption reduces the risk of non-small cell lung cancers with epidermal growth factor receptor mutationsamong Japanese.2008

    • Author(s)
      Matsuo K., HirakiA., Ito H.,KosakaT., Suzuki T.,Hirose K.,Wakai K.,Yatabe Y., Mitsudomi T.
    • Journal Title

      Cancer Sci 99

      Pages: 1202-1208

    • Peer Reviewed
  • [Journal Article] One-carbon metabolism-related gene polymorphisms and risk of breast cancer.2008

    • Author(s)
      Suzuki T., Matsuo K., Hirose K., Hiraki A., Kawase T., Watanabe M., Yamashita T., Yatabe Y., Iwata H., Tajima K.
    • Journal Title

      Carcinogenesis 29

      Pages: 356-362

    • Peer Reviewed
  • [Presentation] 日本人女性におけるDNA修復遺伝子多型と子宮体がんリスクとの関連2011

    • Author(s)
      細野覚代, 他
    • Organizer
      第21回日本疫学会学術総会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-01-22
  • [Presentation] 日本人におけるCYP19A1遺伝子多型と閉経後子宮内膜癌リスクとの関連2010

    • Author(s)
      細野覚代, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-23
  • [Presentation] 日本人閉経後女性における生殖歴関連要因および身体要因と血清ホルモンレベルとの関連2009

    • Author(s)
      広瀬かおる, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-03
  • [Presentation] 日本人女性における飲酒と乳がん発症との関連2009

    • Author(s)
      川瀬孝和, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-03
  • [Presentation] 日本人女性におけるBody Mass Indexの変化と子宮内膜癌リスクについての検討2009

    • Author(s)
      細野覚代, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-03
  • [Presentation] 日本人閉経後女性における身体特性・生活習慣およびその介入の女性ホルモンレベルに与える影響2009

    • Author(s)
      広瀬かおる, 他
    • Organizer
      第19回日本疫学会学術総会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-01-23
  • [Presentation] 愛知県がんセンターにおける大規模病院疫学研究参加非がん女性における初潮年齢の推移の検討2009

    • Author(s)
      城所久美子, 他
    • Organizer
      第19回日本疫学会学術総会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-01-23
  • [Presentation] 日本人女性における食事からのカルシウム、ビタミンD摂取と子宮頸がんリスクとの関連2009

    • Author(s)
      細野覚代, 他
    • Organizer
      第19回日本疫学会学術総会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-01-23
  • [Presentation] 初経年齢の乳がん罹患リスクへの影響は、HER2・ホルモン受容体発現の有無によって異なる2008

    • Author(s)
      松尾恵太郎, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-30
  • [Presentation] 日本人におけるHuman-Leukocyte-Antigen-Aアレルと子宮頸がんリスクとの関連2008

    • Author(s)
      細野覚代, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-30
  • [Presentation] 閉経後女性の血清ホルモン濃度と生活習慣、CYP19A1 の遺伝子多型の関連2008

    • Author(s)
      城所久美子, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29

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Published: 2012-01-26   Modified: 2016-04-21  

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