2010 Fiscal Year Final Research Report
The relation between CYP19 haplotypes and breast cancer risk in Japanese women
| Project/Area Number |
20390179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Aichi Prefectural Institute of Public Health |
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Principal Investigator |
HIROSE Kaoru Aichi Prefectural Institute of Public Health, 企画情報部・健康科学情報, 室長 (00393124)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Keitaro 愛知県がんセンター研究所, 疫学・予防部, 室長 (80393122)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 乳がん / ハプロタイプ / エストロゲン |
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| Research Abstract |
Incidence and death rates of breast cancer in Japan have increased markedly in recently years, especially among postmenopausal women. Many gene polymorphisms of enzymes potentially related to carcinogenesis have been examined for breast cancer risk. Aromatase is one of the key enzymes in estrogen biosynthesis and encoded by CYP19A1. To evaluate impact of CYP19A1 haplotypes on breast cancer risk, we conducted a case-control study. Some haplotyeps in CYP19A1 would influence sex hormones levels, thus suggesting potential importance of CYP19A1 haplotypes on breast cancer risk.
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[Journal Article] HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.2010
Author(s)
Hosono S., Kawase T., Matsuo K., Watanabe M., Kajiyama H., Hirose K., Suzuki T., Kidokoro K., Ito H., Nakanishi T., Yatabe Y., Hamajima N., Kikkawa F., Tajima K.,Tanaka H.
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Journal Title
J Epidemiology. 20(4)
Pages: 295-301
Peer Reviewed
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[Journal Article] Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women.2010
Author(s)
Hosono S., Matsuo K., Kajiyama H., Hirose K., Suzuki T., Kawase T., Kidokoro K., NakanishiT.,Hamajima N., Kikkawa F., Tajima K., Tnanaka H.
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Journal Title
Eur J Clin Nut. 64(4)
Pages: 400-409
Peer Reviewed
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[Journal Article] Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women.2009
Author(s)
KidokoroK.,Ino K.,HiroseK.,Kajiyama H., Hosono S., Suzuki T.,KawaseT., Hiraki A., Hamajima N., Tanaka H., Tajima K., Kikkawa F., Matsuo K.
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Journal Title
J Hum Genetics 54
Pages: 78-85
Peer Reviewed
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[Journal Article] Reduced risk of endometrial cancer from alcohol drinking in Japan.2008
Author(s)
Hosono S., Matsuo K., Kajiyama H., HiorseK., SuzukiT., Hiraki A.,Kawase T., Kidokoro K., Nakanishi T., Hamajima N., Kikkawa F., Tajima K., Tanaka H.
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Journal Title
Cancer Sci 99
Pages: 1195-1201
Peer Reviewed
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