Study on the relationship of the long-term trend of cardiovascular diseases between the transitions of the risk factor development among general population in Japan

2011 Fiscal Year Final Research Report

• Project/Area Number: 20390184
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: KITA Yoshikuni 滋賀医科大学, 医学部, 助教 (30147524)
• Co-Investigator(Kenkyū-buntansha): UESHIMA Hirotsugu 滋賀医科大学, 生活習慣病予防センター, 特任教授 (70144483) ; NAKAMURA Yasuyuki 京都女子大学, 家政学部, 教授 (20144371) ; MATSUI Kenji 独立行政法人国立循環器病研究センター, 研究開発基盤センター, 室長 (60431764) ; TAKASHIMA Naoyuki 滋賀医科大学, 生活習慣病予防センター, 特任助教 (80435883)
• Project Period (FY): 2008 – 2011
• Keywords: 循環器疾患 / 発症登録 / コホート研究 / 死亡予後

Research Abstract

In this study, we conducted a cohort study and a population based registration in cardiovascular diseases (CVD) events. The cohort study of general population in Takashima city (Northwest part of Shiga prefecture) was designed to investigate the risk factors of CVD. We have conducted the second survey of the cohort study from 2008. From the cohort study, we found that arterial stiffness is associated with all-cause mortality and CVD events in general population. Also we have continued to conduct the CVD registry to investigate the incidence rate of CVD in the Takashima city. From the CVD registry, we found that incidence rate of hemorrhagic stroke shows a slight decrease and that of ischemic stroke showed a slight increase between 1990 to 1992 and 1999 to 2001.

Research Products

• [Journal Article] A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval (2012)
  • Author(s): Kim JW, Hong KW, Go MJ, Kim SS, Tabara Y, Kita Y, Tanigawa T, Cho YS, Han BG, Oh B
  • Journal Title: Am J Hum Genet Volume: 91(1) Pages: 180-184
  • Peer Reviewed
• [Journal Article] A Randomized Controlled Trial of Short and Standard-Length Consent Forms for a Genetic Cohort Study: Is Longer Better? (2012)
  • Author(s): Matsui K, Lie RK, Turin TC, Kita Y
  • Journal Title: J Epidemiol Volume: 22(4) Pages: 308-316
  • Peer Reviewed
• [Journal Article] Short-term exposure to air pollution and incidence of stroke and acute myocardial infarction in a Japanese population (2012)
  • Author(s): Turin TC, Kita Y, Rumana N, Nakamura Y, Ueda K, Takashima N, Sugihara H, Morita Y, Ichikawa M, Hirose K, Nitta H, Okayama A, Miura K, Ueshima H
  • Journal Title: Neuroepidemiology Volume: 38(2) Pages: 84-92
  • Peer Reviewed
• [Journal Article] Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity (2012)
  • Author(s): Kobayashi Y, Hirawa N, Tabara Y, Muraoka H, Fujita M, Miyazaki N, Fujiwara A, Ichikawa Y, Yamamoto Y, Ichihara N, Saka S, Wakui H, Yoshida S, Yatsu K, Toya Y, Yasuda G, Kohara K, Kita Y, Takei K, Goshima Y, Ishikawa Y, Ueshima H, Miki T, Umemura S
  • Journal Title: Hypertension Volume: 59(4) Pages: 854-860
  • Peer Reviewed
• [Journal Article] J-MICC Study Group. Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity (2012)
  • Author(s): Hiyoshi M, Uemura H, Arisawa K, Nakamoto M, Hishida A, Okada R, Matsuo K, Kita Y, Niimura H, Kuriyama N, Nanri H, Ohnaka K, Suzuki S, Mikami H, Kubo M, Tanaka H, Hamajima N
  • Journal Title: Gene Volume: 496(2) Pages: 97-102
  • Peer Reviewed
• [Journal Article] Japan Arteriosclerosis Longitudinal Study Group. Association of obesity and other cardiovascular risk factors with stroke the Japan Arteriosclerosis Longitudinal Study--Existing Cohorts Combined (JALS-ECC) (2011)
  • Author(s): Ohashi Y, Shimamoto K, Sato S, Iso H, Kita Y, Kitamura A, Saito I, Kiyohara Y, Kawano H, Nakagawa H, Toyoshima H, Ando T, Taguri M, Haradai A, Ueshima H
  • Journal Title: Nihon Koshu Eisei Zasshi Volume: 58(12) Pages: 1007-1015
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma (2011)
  • Author(s): Chambers JC, Zhang W, Sehmi J, et al.
  • Journal Title: Nat Genet Volume: 43(11) Pages: 1131-1138
  • Peer Reviewed
• [Journal Article] Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk (2011)
  • Author(s): International Consortium for Blood Pressure Genome-Wide Association Studies
  • Journal Title: Nature Volume: 478(7367) Pages: 103-109
  • Peer Reviewed
• [Journal Article] Time lag to hospitalisation and the associated determinants in patients with acute myocardial infarction: the Takashima AMI Registry, Japan (2011)
  • Author(s): Turin TC, Kita Y, Rumana N, Nakamura Y, Takashima N, Sugihara H, Morita Y, Matsui K, Okayama A, Miura K, Ueshima H
  • Journal Title: Emerg Med J. Volume: 28(3) Pages: 239-241
  • Peer Reviewed
• [Journal Article] Ischemic stroke subtypes and risk factors: the probable bias arisen from the classification style across studies (2011)
  • Author(s): Turin TC, Kita Y, Ueshima H
  • Journal Title: Stroke Volume: 42(1) Pages: ell-2
  • Peer Reviewed
• [Journal Article] Diurnal variation in onset of hemorrhagic stroke is independent of risk factor status: Takashima Stroke Registry (2010)
  • Author(s): Turin TC, Kita Y, Rumana N, Takashima N, Ichikawa M, Sugihara H, Morita Y, Hirose K, Murakami Y, Miura K, Okayama A, Nakamura Y, Abbott RD, Ueshima H
  • Journal Title: Neuroepidemiology Volume: 34(1) Pages: 25-33
  • Peer Reviewed
• [Journal Article] Ambient weather conditions and the onset of acute myocardial infarction: The consociation between triggering factors and conventional risk factors (2010)
  • Author(s): Turin TC, Rumana N, Kita Y, Nakamura Y, Miura K, Ueshima H
  • Journal Title: J Cardiol Volume: 55(2) Pages: 283-284
  • Peer Reviewed
• [Journal Article] Circaseptan variation in case-fatality rate for patients with acute subarachnoid hemorrhage (Takashima Stroke Registry 1988-2003) (2010)
  • Author(s): Turin TC, Kita Y, Rumana N, Takashima N, Ichikawa M, Sugihara H, Morita Y, Hirose K, Miura K, Okayama A, Nakamura Y, Ueshima H
  • Journal Title: J Clin Neurosci Volume: 17(7) Pages: 869-873
  • Peer Reviewed
• [Journal Article] Brachial-ankle pulse wave velocity predicts all-cause mortality in the general population: findings from the Takashima study, Japan (2010)
  • Author(s): Turin TC, Kita Y, Rumana N, Takashima N, Kadota A, Matsui K, Sugihara H, Morita Y, Nakamura Y, Miura K, Ueshima H
  • Journal Title: Hypertens Res Volume: 33(9) Pages: 922-925
  • Peer Reviewed
• [Journal Article] Ueshima H. Ischemic stroke subtypes in a Japanese population: Takashima Stroke Registry (2010)
  • Author(s): Turin TC, Kita Y, Rumana N, Nakamura Y, Takashima N, Ichikawa M, Sugihara H, Morita Y, Hirose K, Okayama A, Miura K
  • Journal Title: Stroke Volume: 41(9) Pages: 1871-1876
  • Peer Reviewed
• [Journal Article] 一般地域住民にみるゲノム疫学研究への参加・不参加行動選択の理由 (2010)
  • Author(s): 松井健志, 喜多義邦
  • Journal Title: 日本公衆衛生雑誌 Volume: 57(11) Pages: 977-987
  • Peer Reviewed
• [Journal Article] Trend of stroke incidence in a Japanese population: Takashima stroke registry (2009)
  • Author(s): Kita Y, Turin TC, Ichikawa M, Sugihara H, Morita Y, Tomioka N, Rumana N, Okayama A, Nakamura Y, Abbott RD, Ueshima H
  • Journal Title: Int J Stroke Volume: 4(4) Pages: 241-249
  • Peer Reviewed
• [Journal Article] The Time Interval Window between Stroke Onset and Hospitalization and Its Related Factors (2009)
  • Author(s): Turin TC, Kita Y, Rumana N, Takashima N, Ichikawa M, Sugihara H, Morita Y, Miura K, Okayama A, Nakamura Y, Ueshima H
  • Journal Title: Neuroepidemiology Volume: 33(3) Pages: 240-246
  • Peer Reviewed
• [Journal Article] Incidence, admission and case-fatality of acute myocardial infarction: weekend versus weekday in a Japanese population: 16-year results from Takashima AMI Registry (1988-2003) (2009)
  • Author(s): Turin TC, Kita Y, Rumana N, Sugihara H, Morita Y, Tomioka N, Okayama A, Nakamura Y, Ueshima H
  • Journal Title: Eur J Epidemiol Volume: 24(2) Pages: 93-100
  • Peer Reviewed
• [Journal Article] Seasonal pattern of incidence and case fatality of acute myocardial infarction in a Japanese population (from the Takashima AMI Registry, 1988 to 2003) (2008)
  • Author(s): Rumana N, Kita Y, Turin TC, Murakami Y, Sugihara H, Morita Y, Tomioka N, Okayama A, Nakamura Y, Ueshima H
  • Journal Title: Am J Cardiol Volume: 102(10) Pages: 1307-1311
  • Peer Reviewed
• [Presentation] 地域一般住民を対象にした橈骨Augmentation Indexと心腎機能指標との関連の検討 (2011)
  • Author(s): 喜多義邦, 高嶋直敬, Chowdhury Turin, Nahid Rumana, 門田文, 中村保幸, 三浦克之, 上島弘嗣
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮市
  • Year and Date: 20110000
• [Presentation] A cardiovascular disease through the population-based disease registry in Japan; Overview of the Takashima AMI and stroke registry (2011)
  • Author(s): Turin TC, Kita Y, Ueshima H
  • Organizer: 第75回日本循環器病学会総会シンポジューム
  • Place of Presentation: 横浜
  • Year and Date: 20110000
• [Presentation] 脳卒中の発症率は増えているか?-高島における脳卒中地域発症登録研究より- (2010)
  • Author(s): 喜多義邦、Turin TC、中村保幸、Nahid Rumana、市川正春、森田 豊、広瀬邦彦、三浦克之、上島弘嗣
  • Organizer: 第35回日本脳卒中学会総会シンポジューム
  • Place of Presentation: 盛岡
  • Year and Date: 20100000
• [Presentation] 日本の心臓血管疾患の疫学研究 大規模コホート統合研究(JALS)喫煙と循環器疾患リスク Japan Arteriosclerosis Longitudinal Study 0次研究の成果から (2010)
  • Author(s): 喜多義邦, 岡山明, 大橋靖雄, 原田亜紀子, 田栗正隆, 篠崎智大, 上島弘嗣
  • Organizer: 第58回日本心臓病学会シンポジューム
  • Place of Presentation: 東京
  • Year and Date: 20100000
• [Presentation] 地域での脳卒中・心筋梗塞罹患率の推移 (2009)
  • Author(s): 喜多義邦, Tanvir Chowdhury Turin, 高嶋直敬, Nahid Rumana, 中村保幸, 三浦克之, 上島弘嗣
  • Organizer: 第41回日本動脈硬化学会総会シンポジューム
  • Place of Presentation: 下関
  • Year and Date: 20090000
• [Presentation] 一般地域住民におけるPWVと高感度CRPの関連性Takashima Cohort Study (2008)
  • Author(s): 高嶋直敬, Turin TC, 喜多義邦, 中村保幸, 三浦克之, 上島弘嗣
  • Organizer: 第31回日本高血圧学会総会
  • Year and Date: 20080000
• [Book] 第1章循環器疾患の疫学(6)発症登録からみた置換率の動向 NIPPON DATAからみた循環器疾患のエビデンス (2008)
  • Author(s): 上島弘嗣 編著, 喜多義邦 著
  • Total Pages: P39-42
  • Publisher: 日本医事新報社
• [Remarks]
  • URL: http://www.stroke-project.com
• [Remarks]
  • URL: http://hs-web.shiga-med.ac.jp/Study.htm1#hassyo