2010 Fiscal Year Final Research Report
Genetic factors and gene-environmental interaction in pancreatic cancer in Asia population.
| Project/Area Number |
20390192
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
TANAKA Hideo Aichi Cancer Center Research Institute, 疫学・予防部, 部長 (60470168)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Keitaro 愛知県がんセンター(研究所), 疫学・予防部, 室長 (80393122)
SUZUKI Takeshi 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (70416163)
KAWASE Takakazu 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (30463194)
HOSONO Satoyo 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (80402600)
ITO Hidemi 愛知県がんセンター(研究所), 疫学・予防部, 室長 (90393123)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAKI Akio 岡山大学, 保健管理センター, 助教 (70443455)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌 / 社会医学 / 衛生 / 疫学 / 遺伝子多型 |
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| Research Abstract |
To elucidate gene-environmental interaction in pancreatic cancer in Asia population, we conducted hospital-based case control studies in Japan. We found that polymorphisms of MTHFR, ADH1B and ALDH2 showed significant interation with alcohol consumption for the development of pancreatic cancer. In addition, we found that ABO blood group alleles was significantly associated with the risk of pancreatic cancer in a Japanese population. We also demonstrated that chronic hepatitis B virus infection was significantly associated with cholangio cellular carcinoma in a cohort study.
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Research Products
(12 results)
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[Journal Article] ABO blood group alleles and the risk of pancreatic cancer in Japanese population.2011
Author(s)
Nakao M, Matsuo K, Hosono S, Ogata S, Ito H, Watanabe M, Mizuno N, Iida S, Satoh S, Yatabe Y, Yamao K, Ueda R, Tajima K, Tanaka H
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Journal Title
Cancer Sci. 102(5)
Pages: 1076-1080
Peer Reviewed
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[Journal Article] Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese.2009
Author(s)
Kanda J, Matsuo K, Suzuki T, Kawase T, Hiraki A, Watanabe M, Mizuno N, Sawaki A, Yamao K, Tajima K, Tanaka H
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Journal Title
Cancer Sci 100
Pages: 296-302
Peer Reviewed
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[Journal Article] Impact of multiple alcohol dehydrogenase (ADH) gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese Population.2009
Author(s)
Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H
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Journal Title
Cancer Epidemiol Biomarker Prev 18
Pages: 3097-3102
Peer Reviewed
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[Journal Article] Proposal for a Cooperative Study on Population-based Cancer Survival in Selected Registries in East Asia.2009
Author(s)
Tanaka H, Tanaka M, Chen W, Park S, Jung KW, Chiang CJ, Lai MS, Mirasol-Lumague MR, Laudico AS, Sinuraya ES, Nishino Y, Shibata A, Fujita M, Soda M, Naito M, Tsukuma H, Moore MA, Ajiki W.
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Journal Title
Asian Pac J Cancer Prev. 10
Pages: 1191-1198
Peer Reviewed
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[Journal Article] Reduced risk of hepatocellular carcinoma after interferon therapy in aged patients with chronic hepatitis C is limited to sustained virological responders.2009
Author(s)
Imai Y, Tamura S, Tanaka H, Hiramatsu N, Kiso S, Doi Y, Inada M, Nagase T, Kitada T, Imanaka K, Fukuda K, Takehara T, Kasahara A, Hayashi N.
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Journal Title
J Viral Hepat. 17
Pages: 185-191
Peer Reviewed
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[Journal Article] Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk.2008
Author(s)
Suzuki T, Matsuo K, Sawaki A, Mizuno N, Hiraki A, Kawase T, Watanabe M, Nakamura T, Yamao K, Tajima K, Tanaka H
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Journal Title
Cancer Epidemiol Biomarkers Prev 17
Pages: 2742-2747
Peer Reviewed
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