2010 Fiscal Year Final Research Report
Studies on endogenous neuronal mediator with responsibility for anti-dementia effect of Kampo medicine
| Project/Area Number |
20390197
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
MATSUMOTO Kinzo University of Toyama, 和漢医薬学総合研究所, 教授 (10114654)
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| Co-Investigator(Kenkyū-buntansha) |
TSUNEYAMA Koichi 富山大学, 大学院・医学薬学研究部(医学), 准教授 (10293341)
TANAKA Ken 富山大学, 和漢医薬学総合研究所, 准教授 (60418689)
MURAKAMI Yukihisa 富山大学, 和漢医薬学総合研究所, 助教 (00377269)
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| Co-Investigator(Renkei-kenkyūsha) |
SIBAHARA Naotoshi 富山大学, 和漢医薬学総合研究所, 教授 (10272907)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 認知症モデル / 漢方薬 / メディエータ / 脳虚血 / 加齢 |
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| Research Abstract |
In this study, we have demonstrated the anti-dementia effects of chotosan, yokukansan, and kangenkaryu using animal models of cognitive deficits. We have also suggested that vascular endothelial growth factor and platelet-derived growth factors, as well as facilitation of central cholinergic systems and neuroplasticity systems, are involved in the action of these crude drugs. The present findings that VEGF/PDGF and their receptors are co-localized with NMDA-type glutamate receptors in the cerebral cortical neurons allowed us to infer that VEGF/PDGF may act as endogenous factors that mediate the anti-dementia effects of chotosan, kangen-karyu, and yokukansan.
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Research Products
(40 results)
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[Journal Article]2009
Author(s)
Cuia H-S., Murakami Y., Hori H., Zhao Q., Obi R., Matsumoto K.
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Journal Title
Biol.Pharm.Bull. 32
Pages: 79-85
Peer Reviewed
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