2010 Fiscal Year Final Research Report
Translational research on intractable neuro-metabolic disorders
| Project/Area Number |
20390199
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kagoshima University |
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Principal Investigator |
INUI Akio Kagoshima University, 医歯学総合研究科, 教授 (80168418)
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| Co-Investigator(Renkei-kenkyūsha) |
ANO Akira 鹿児島大学, 医歯学総合研究科, 教授 (30178800)
AMANAKA Hiroshi 鹿児島大学, 臨床心理学研究科, 教授 (60182581)
HOU De-Xing 鹿児島大学, 農学部, 准教授 (90305160)
HORIUCHI Masahisa 鹿児島大学, 歯学総合研究科, 准教授 (50264403)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 遺伝子 / 医療・福祉 / 神経医学 / トランスレーショナルリサーチ / 臨床 |
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| Research Abstract |
The translational research was conducted on intractable nuero-metablic disorders such as congenital diseases including carnitine carrier deficiency, citrin deficiency and chorea acantosis, and maltifactorial diseases including cancer cachexia, eating disorders and mood disorders. JVS mouse and animal models of cancer cachexia and citrin deficiency were created and used on pathological analysis. New treatment methods, such as acetylcarnitine, pyruvic acid, ghrelin agonist and Rikkunshito, were created or applied clinically from this research work.
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[Journal Article] Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa.2010
Author(s)
Ogiso K, Asakawa A, Amitani H, Nakahara T, Ushikai M, Haruta I, Koyama K, Amitani M, Harada T, Yasuhara D, Inui A.
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Journal Title
Peptides 32(1)
Pages: 150-153
Peer Reviewed
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[Journal Article] Failure of the feeding response to fasting in carnitie-deficient juvenile visecal steatosis (JVS) mice : involvement of defective acly-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus.2009
Author(s)
Sakoguchi T, Horiuchi M, Asakawa A, Ushikai M, Yoshida G, Fujimiya M, Kato I, Nakazato M, Takeuchi T, Saheki T, Inui A.
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Journal Title
Biochim Biophys Acta. 1792(11)
Pages: 1087-1093
Peer Reviewed
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[Journal Article] Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population.2009
Author(s)
Numata S, Iga J, Nakataki M, Tayoshi S, Taniguchi K, Sumitani S, Tomotake M, Tanahashi T, Itakura M, Kamegaya Y, Tatsumi M, Sano A, Asada T, Kunugi H, Ueno S, Ohmori T.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet. 50B(4)
Pages: 527-534
Peer Reviewed
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[Journal Article] Ghrelin Treatment of Chronic Kidney Disease : Improvements in Lean Body Mass and Cytokine Profile.2008
Author(s)
Deboer MD, Zhu X, Levasseur PR, Inui A, Hu Z, Han G, Mitch WE, Taylor JE, Halem HA, Dong JZ, Datta R, Culler MD, Marks DL.
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Journal Title
Endocrinology 149(2)
Pages: 827-835
Peer Reviewed
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