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2010 Fiscal Year Final Research Report

Invasive pancreatic cancer specific apoptosis induction therapy by microRNA.

Research Project

  • PDF
Project/Area Number 20390202
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

SHIMOSEGAWA Toru  Tohoku University, 大学院・医学系研究科, 教授 (90226275)

Co-Investigator(Kenkyū-buntansha) SATOH Kennichi  東北大学, 病院, 講師 (10282055)
HAMADA Shin  東北大学, 病院, 医員 (20451560)
Project Period (FY) 2008 – 2010
Keywords膵癌 / EMT / microRNA
Research Abstract

We performed the comprehensive analysis of microRNA expression profile to identify novel microRNAs which regulate invasiveness of pancreatic cancer. The cluster analysis identified miR-126 as a significantly down-regulated microRNA in invasive pancreatic cancer, which attenuates migration and invasion of pancreatic cancer cells. Furthermore, ADAM9 was newly identified as a target gene of miR-126, of which knockdown resulted in the decreased migration and invasion of pancreatic cancer cells. The miR-126/ADAM9 pathway could be a novel therapeutic target of invasive pancreatic cancer.

  • Research Products

    (8 results)

All 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2.2011

    • Author(s)
      Hamada S, Satoh K, Hirota M, Kanno A, Umino J, Ito H, Masamune A, Kikuta K, Kume K, Shimosegawa T.
    • Journal Title

      J Cell Physiol. [Epub ahead of print]

      Pages: doi:10.1002/jcp.22781.

    • Peer Reviewed
  • [Journal Article] Biomarkers of pancreatic cancer.2011

    • Author(s)
      Hamada S, Shimosegawa T.
    • Journal Title

      Pancreatology. 11 Suppl 2

      Pages: 14-19

    • Peer Reviewed
  • [Journal Article] Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoma.2011

    • Author(s)
      Hamada S, Satoh K, Hirota M, Kanno A, Ishida K, Umino J, Ito H, Kikuta K, Kume K, Masamune A, Katayose Y, Unno M, Shimosegawa T.
    • Journal Title

      Cancer Sci. 102(1)

      Pages: 150-156

    • Peer Reviewed
  • [Journal Article] Evaluation of MSX2 mRNA in brush cytology specimens distinguished pancreatic carcinoma from chronic pancreatitis.2011

    • Author(s)
      Satoh K, Hamada S, Kanno A, Ishida K, Ito H, Hirota M, Masamune A, Egawa S, Unno M, Shimosegawa T.
    • Journal Title

      Cancer Sci. 102(1)

      Pages: 157-161

    • Peer Reviewed
  • [Journal Article] Prediction of invasive carcinoma in branch type intraductal papillary mucinous neoplasms of the pancreas.2010

    • Author(s)
      Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H, Masamune A, Asakura T, Shimosegawa T.
    • Journal Title

      J Gastroenterol. 45(9)

      Pages: 952-959

    • Peer Reviewed
  • [Presentation] THE TRANSCRIPTIONAL REGULATION OF CANCER STEM CELL-RELATED GENE ABCG2 BY THE HOMEOBOX GENE MSX2.2011

    • Author(s)
      Hamada S, Satoh K,, Hirota M, Kanno A, Masamune A, Kikuta K, Kume K, Unno J, Shimosegawa T.
    • Organizer
      International Association of Pancreatology & Indian Pancreas Club 2011
    • Place of Presentation
      Cochin, India
    • Year and Date
      2011-02-13
  • [Presentation] The regulation of stem cell related genes by the homeobox gene MSX2 in pancreatic cancer cells.2010

    • Author(s)
      Hamada S, Satoh K, Hirota M, Kanno A, Ito H, Shimosegawa T.
    • Organizer
      DDW 2010
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-05-02
  • [Presentation] ヒト膵癌におけるstem cell-like phenotypeとmicroRNA発現プロファイル2010

    • Author(s)
      濱田晋, 佐藤賢一, 下瀬川徹
    • Organizer
      第96回 消化器病学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2010-04-23

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Published: 2012-01-26   Modified: 2016-04-21  

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