Metabolic abnormalities in hepatitis C and its impact on the progression of liver disease

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390204
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: KOIKE Kazuhiko The University of Tokyo, 医学部附属病院, 教授 (80240703)
• Co-Investigator(Kenkyū-buntansha): YOTSUYANAGI Hiroshi 東京大学, 医学部附属病院, 准教授 (30251234)
• Project Period (FY): 2008 – 2010
• Keywords: ウイルス肝炎 / 癌 / 肝線維化 / 脂質代謝 / インスリン抵抗性

Research Abstract

We have shown that lipid metabolism disturbance and insulin resistance frequently occur in hepatitis C, and have been studying the underlying mechanism. Hepatitis C virus (HCV) gives an impact on the progression of liver disease in hepatitis C by modulating the expression of transcription factors such as SREBP-1c, phosphorylation of signal proteins, expressions of lipid metabolism enzymes and the secretion of apolipoproteins. Also, HCV augments the production of reactive oxygen species and compromises the host anti-oxidant system, thereby leading to the overproduction of oxidative stress, which is the most notable characteristic of hepatitis C.

Research Products

• [Journal Article] Living donor liver transplantations in HIV- and hepatitis C virus-coinfected hemophiliacs: Experience in a Single Center. (2011)
  • Author(s): Tsukada K, Sugawara Y, Kaneko J, Tamura S, Tachikawa N, Morisawa Y, Okugawa S, Kikuchi Y, Oka S, Kimura S, Yatomi Y, Makuuchi M, Kokudo N, Koike K.
  • Journal Title: Transplantation, [Epub ahead of print] PubMed PMID Pages: 21593704
• [Journal Article] Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on a non-porous column for differential proteomics analysis. (2011)
  • Author(s): Koshiyama A, Ichibangase T, Moriya K, Koike K, Yazawa I, Imai K.
  • Journal Title: J Chromatogr A, [Epub ahead of print] PubMed PMID Pages: 21511262
• [Journal Article] Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK. (2011)
  • Author(s): Nakagawa H, Hirata Y, Takeda K, Hayakawa Y, Sato T, Kinoshita H, Sakamoto K, Nakata W, Hikiba Y, Omata M, Yoshida H, Koike K, Ichijo H, Maeda S.
  • Journal Title: Hepatology, [Epub ahead of print] PubMed PMID Pages: doi:10.1002/hep.24357, 21488081
• [Journal Article] Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines. (2011)
  • Author(s): Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K.
  • Journal Title: Hepatol Int, [Epub ahead of print] PubMed PMID Pages: 21484132
• [Journal Article] Hepatocellular carcinoma with extrahepatic metastasis: Clinical features and prognostic factors. (2011)
  • Author(s): Uchino K, Tateishi R, Shiina S, Kanda M, Masuzaki R, Kondo Y, Goto T, Omata M, Yoshida H, Koike K.
  • Journal Title: Cancer, [Epub ahead of print] PubMed PMID Pages: 21437884
• [Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. (2011)
  • Author(s): Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, Hosono N, Otuska M, Tateishi R, Omata M, Nakagawa H, Koike K, Kamatani N, Kubo M, Nakamura Y, Matsuda K.
  • Journal Title: Nat Genet 43(5) Pages: 455-458
• [Journal Article] Autotaxin as a novel serum marker of liver fibrosis. (2011)
  • Author(s): Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y.
  • Journal Title: Clin Chim Acta 412(13-14) Pages: 1201-1206
• [Journal Article] NegroThe global health burden of hepatitis C virus infection. (2011)
  • Author(s): D.Kershenobich, H.A.Razavi, C.L.Cooper, A.Alberti, G.M.Dusheiko, S.Pol, E.Zuckerman, K.Koike, K.-H.Han, C.M.Wallace, S.Zeuzem , F.
  • Journal Title: Liver Int 31(S2) Pages: 4-17
• [Journal Article] A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. (2011)
  • Author(s): W.Sievert, I.Altraif, H.A.Razavi, A.Abdo, E.A.Ahmed, A.AlOmair, D.Amarapurkar, C.-H.Chen, X.Dou, H.El Khayat, M.elShazly, G.Esmat, R.Guan, K.-H.Han, K.Koike, A.Largen, G.McCaughan, S.Mogawer, A.Monis, A.Nawaz, T.Piratvisuth, F.M.Sanai, A.I.Sharara, S.Sibbel, A.Sood, D.J.Suh, C.Wallace, K.Young, F.Negro.
  • Journal Title: Liver Int 31(S2) Pages: 61-80
• [Journal Article] The Japan NASH Study Group, The Ministry of Health, Labour and Welfare of Japan.Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. (2011)
  • Author(s): Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y, Shima T, Kanbara Y,Saibara T, Mori T, Kawata S, Uto H, Takami S, Sumida Y, Takamura T, Kawanaka M, Okanoue T
  • Journal Title: Clin Gastroenterol Hepatol 9(5) Pages: 428-433
• [Journal Article] Effect of treatment with polynsatured fatty acids on HCV-or diet-induced fatty liver. (2011)
  • Author(s): Koike K, Miyoshi H, Yotsyanagi H, Moriya K.
  • Journal Title: J Hepatol 54 Pages: 1326
• [Journal Article] Plant sterols increased IL-6 and TNF-alpha secretion from macrophages, but to a lesser extent than cholesterol. (2011)
  • Author(s): Kurano M, Iso-O N, Hara M, Noiri E, Koike K, Kadowaki T, Tsukamoto K.
  • Journal Title: J Atheroscler Thromb, [Epub ahead of print] PubMed PMID Pages: 21266789
• [Journal Article] Utility of contrast enhanced ultrasonography with sonazoid in radiofrequency ablation for hepatocellular carcinoma. (2011)
  • Author(s): Masuzaki R, Shiina S, Tateishi R, Yoshida H, Goto E, Sugioka Y, Kondo Y, Goto T, Ikeda H, Omata M, Koike K.
  • Journal Title: J Gastroenterol Hepatol 26(4) Pages: 759-764
• [Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (2011)
  • Author(s): Miyoshi H, Moriya K, Tsutsumi T Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
  • Journal Title: J Hepatol 54 Pages: 432-438
• [Journal Article] Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer. (2011)
  • Author(s): Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Kinoshita H, Nakata W, Takahashi R, Tateishi K, Tada M, Akanuma M, Yoshida H, Takeda K, Ichijo H, Omata M, Maeda S, Koike K.
  • Journal Title: Proc Natl Acad Sci USA 108 Pages: 780-785
• [Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis. (2011)
  • Author(s): Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
  • Journal Title: Liver Int 31 Pages: 197-205
• [Journal Article] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients. (2010)
  • Author(s): Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
  • Journal Title: Int J Cancer, [Epub ahead of print] PubMed PMID Pages: 21170963
• [Journal Article] Impact of Changes in Obesity Parameters on Glucose Metabolism and Insulin Resistance Over a One-Year Period. (2010)
  • Author(s): Sakamoto A, Ishizaka Y, Toda EI, Nagai R, Koike K, Yamakado M, Ishizaka N.
  • Journal Title: J Atheroscler Thromb 17 Pages: 1246-1255
• [Journal Article] Expression of alpha-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor. (2010)
  • Author(s): Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Ikeda H, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Koike K, Shirataki H, Fujiwara K.
  • Journal Title: Int J Oncol 37 Pages: 1417-1423
• [Journal Article] Lipid metabolism and pathogenesis of liver disease in hepatitis C viral infection. (2010)
  • Author(s): Koike K, Tsutsumi T, Yotsuyanagi H, Moriya K.
  • Journal Title: Oncology 78 Suppl 1 Pages: 24-30
• [Journal Article] Thrombocytopenia is more severe in advanced chronic hepatitis C than B with the same grade of splenomegaly. (2010)
  • Author(s): Tejima K, Masuzaki R, Ikeda H, Yoshida H, Tateishi R, Sugioka Y, Kume Y, Okano T, Iwai T, Gotoh H, Katoh S, Suzuki S, Yatomi Y, Omata M, Koike K.
  • Journal Title: J Gastroeterol 45 Pages: 876-884
• [Journal Article] Cryptococcus gattii Genotype VGIIa Infection in Man, Japan (2010)
  • Author(s): Okamoto K, Hatakeyama S, Itoyama S, Nukui Y, Yoshino Y, Kitazawa T, Yotsuyanagi H, Reiko Ikeda, SugitaT, Koike K.
  • Journal Title: 2007.Emerg Infect Dis 16 Pages: 1155-1157
• [Journal Article] Association between gamma-glutamyl transferase levels and insulin resistance according to alcohol consumption and number of cigarettes smoked. (2010)
  • Author(s): Ishizaka N, Ishizaka Y, Toda E, Yamakado M, Koike K, Nagai R.
  • Journal Title: J Atheroscler Thromb 17 Pages: 476-485
• [Journal Article] Plasma sphingosine 1-phosphate level is reduced in patients with chronic liver disease caused by hepatitis C. (2010)
  • Author(s): Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, OkuboS, Yokota H, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Koike K, Yatomi Y.
  • Journal Title: Clin Chim Acta 411 Pages: 765-770
• [Journal Article] Effect of nucleoside analogue-interferon sequential therapy on patients with acute exacerbation of chronic hepatitis B. (2010)
  • Author(s): Okuse C, Yotsuyanagi H, Yamada N, Okamoto M, Ikeda H, Kobayashi M, Fukuda Y, Takahashi H, Nagase Y, Suzuki Y, Matsunaga K, Ishii T, Matsumoto N, Koike K, Suzuki M, Itoh F.
  • Journal Title: Hepatol Res 40 Pages: 461-469
• [Journal Article] RNA dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand. (2010)
  • Author(s): Kanamori H, Yuhashi K, Ohnishi S, Koike K, Kodama T.
  • Journal Title: J Gen Virol 91 Pages: 1207-1212
• [Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells. (2010)
  • Author(s): Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
  • Journal Title: J Med Virol 82 Pages: 776-792
• [Journal Article] Expression of pituitary tumor transforming gene 1 (PTTG1)/securin in hepatitis B virus-associated liver diseases: Evidence for a hepatitis B virus X protein-mediated inhibition of PTTG1 ubiquitination and degradation. (2010)
  • Author(s): Molina-Jimenez F, Benedicto I, Murata M, Martin-Vilchez S, Seki T, Pintor-Toro JA, Tortolero M, Moreno-Otero R, Okazaki K, Koike K, Barbero JL, Matsuzaki K, Majano PL, Lopez-Cabrera M.
  • Journal Title: Hepatology 51 Pages: 777-787
• [Journal Article] Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin. (2010)
  • Author(s): Hmwe SS, Aizakia H, Date T, Murakami K, Ishii K, Miyamura T, Koike K, Wakita T, Suzuki T.
  • Journal Title: Antiviral Res 85 Pages: 520-524
• [Journal Article] Effects of the AT(1) receptor blocker losartan and the calcium channel blocker benidipine on the accumulation of lipids in the kidney of a rat model of metabolic syndrome. (2010)
  • Author(s): Ishizaka N, Hongo M, Matsuzaki G, Furuta K, Saito K, Sakurai R, Sakamoto A, Koike K, Nagai R.
  • Journal Title: Hypertens Res 33 Pages: 263-268
• [Journal Article] PERFECT STUDY GROUP.Prolonged treatment with PEG-IFN a-2b and ribavirin can improve SVR in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan. (2010)
  • Author(s): Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M
  • Journal Title: Hepatol Res 40 Pages: 135-144
• [Journal Article] Animal models for hepatitis C and related liver disease. (2010)
  • Author(s): Koike K, Moriya K, Matsuura Y.
  • Journal Title: Hepatol Res 40 Pages: 69-82
• [Journal Article] Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals. (2010)
  • Author(s): Ishizaka N, Ishizaka Y, Toda A, Tani M, Toda E, Koike K, Yamakado M, Nagai R.
  • Journal Title: J Rheumatol 37 Pages: 410-416
• [Journal Article] Impact of changes in waist circumference and BMI over one-year period on serum lipid data in Japanese individuals. (2009)
  • Author(s): Ishizaka N, Ishizaka Y, Toda E, Koike K, Nagai R, Yamakado M.
  • Journal Title: J Atheroscler Thromb 16 Pages: 764-771
• [Journal Article] Impacts of changes in obesity parameters for the prediction of blood pressure change in Japanese individuals. (2009)
  • Author(s): Ishizaka N, Ishizaka Y, Toda E, Koike K, Yamakado M, Nagai R.
  • Journal Title: Kidney Blood Press Res 32 Pages: 421-427
• [Journal Article] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: Analysis using mouse model and cultured cells. (2009)
  • Author(s): Moriya K, Miyoshi H, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Yotsuyanagi H, Moriishi K, Matsuura Y, Suzuki T, Miyamura T, Koike K.
  • Journal Title: Am J Pathol 175 Pages: 1515-1524
• [Journal Article] Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperone, prohibitin, in cells expressing hepatitis C virus core protein. (2009)
  • Author(s): Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T, Koike K.
  • Journal Title: Hepatology 50 Pages: 378-386
• [Journal Article] Chronic hepatitis C in patients coinfected with human immunodeficiency virus in Japan: a retrospective multicenter analysis. (2009)
  • Author(s): Yotsuyanagi H, Kikuchi Y, Tsukada K, Nishida K, Kato M, Sakai H, Takamatsu J, Hige S, Chayama K, Moriya K, Koike K.
  • Journal Title: Hepatol Res 39 Pages: 657-663
• [Journal Article] Association between changes in obesity parameters and incidence of chronic kidney disease in Japanese individuals. (2009)
  • Author(s): Ishizaka Y, Ishizaka N, Tani M, Toda A, Toda EI, Koike K, Nagai R, Yamakado M.
  • Journal Title: Kidney Blood Press Res 32 Pages: 141-149
• [Journal Article] Hepatitis B virus X protein shifts hepatic Smad3-mediated signaling from tumor-suppression to oncogenesis in chronic hepatitis B. (2009)
  • Author(s): Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Uemura Y, Sakaida N, Fujisawa J, Seki T, Koike K, Okazaki K.
  • Journal Title: Hepatology 49 Pages: 1203-1217
• [Journal Article] Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart. (2009)
  • Author(s): Hongo M, Ishizaka N, Furuta K, Yahagi N, Saito K, Sakurai R, Matsuzaki G, Koike K, Nagai R.
  • Journal Title: Eur J Pharmacol 604 Pages: 87-92
• [Journal Article] A single amino acid of toll-like receptor 4 that is pivotal for its signaltransduction and subcellular localization. (2009)
  • Author(s): Yanagimoto S, Tatsuno K, Okugawa S, Kitazawa T, Tsukada K, Koike K, Kodama T, Kimura S, Shibasaki Y, Ota Y.
  • Journal Title: J Biol Chem 284 Pages: 3513-3520
• [Journal Article] Association between metabolic syndrome and carotid atherosclerosis in individuals without diabetes based on the oral glucose tolerance test. (2009)
  • Author(s): Ishizaka N, Ishizaka Y, Yamakado M, Toda E, Koike K, Nagai R.
  • Journal Title: Atherosclerosis 204 Pages: 619-623
• [Journal Article] Identification of a novel mutation for phytosterolemia.Genetic analysis of two cases. (2009)
  • Author(s): Togo M, Hashimoto Y, Iso-O N, Kurano M, Hara M, Kadowaki T, Koike K, Tsukamoto K.
  • Journal Title: Clin Chim Acta 401 Pages: 165-169
• [Journal Article] Steatosis, Liver injury and hepatocarcinogenesis in hepatitis C viral infection. (2009)
  • Author(s): Koike K.
  • Journal Title: J Gastroenterol 44supl Pages: 82-88
• [Journal Article] Limitation of immunoaffinity column for the removal of abundant proteins from plasma in quantitative plasma proteomics. (2009)
  • Author(s): Ichibangase T, Moriya K, Koike K, Imai K.
  • Journal Title: BiomedChromatogr 23 Pages: 480-487
• [Journal Article] Colonization and/or infection with methicillin-resistant Staphylococcus aureus after living donor liver transplantation: a case control study. (2008)
  • Author(s): Hashimoto M, Sugawara Y, Tamura S, Kaneko J, Matsui Y, Togashi J, Moriya K, Koike K, Makuuchi M.
  • Journal Title: BMC Infectious Diseases 8 Pages: 155
• [Journal Article] PPAR-alpha is essential for severe hepatic steatosis and hepatocellular carcinoma induced by HCV core protein. (2008)
  • Author(s): Tanaka N, Moriya K, Kiyosawa K, Koike K, Gonzalez FJ, Aoyama T.
  • Journal Title: J Clin Invest 118 Pages: 683-694
• [Journal Article] Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis. (2008)
  • Author(s): Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T.
  • Journal Title: Int J Cancer 122 Pages: 124-131
• [Journal Article] Prevalence of hepatitis B virus infection in patients with human immunodeficiency virus in Japan. (2008)
  • Author(s): Koike K, Kikuchi Y, Kato M, Takamatsu J, Shintani Y, Tsutsumi T, Fujie H, Miyoshi H, Moriya K, Yotsuyanagi H.
  • Journal Title: Hepatol Res 38 Pages: 310-314
• [Journal Article] Are serum carcinoembryonic antigen levels associated with carotid atherosclerosis in Japanese men? (2008)
  • Author(s): Ishizaka N, Ishizaka Y, Toda EI, Koike K, Yamakado M, Nagai R.
  • Journal Title: Arterioscler Thromb Vasc Biol 28 Pages: 160-165
• [Journal Article] Effect of treatment with interferon alpha-2b and ribavirin in patients infected with genotype 2 hepatitis C virus. (2008)
  • Author(s): Nagase Y, Yotsuyanagi H, Okuse C, Yasuda K, Kato T, Koike K, Suzuki M, Nishioka K, Iino S, Itoh F.
  • Journal Title: Hepatol Res 38 Pages: 252-258
• [Journal Article] Methicillin-resistant Staphylococcus aureus infection after living-donor liver transplantation in adults. (2008)
  • Author(s): Hashimoto M, Sugawara Y, Tamura S, Kaneko J, Matsui Y, Moriya K, Koike K, Makuuchi M.
  • Journal Title: Transpl Infect Dis 10 Pages: 110-116
• [Journal Article] Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis. (2008)
  • Author(s): Koike K, Tsutsumi T, Miyoshi H, Shinzawa S, Shintani Y, Fujie H, Yotsuyanagi H, Moriya K.
  • Journal Title: J Gastroenterol Hepatol 23 Pages: S87-S91
• [Journal Article] Experimental models of hepatocellular carcinoma. (2008)
  • Author(s): Newell P, Villanueva A, Friedman SL, Koike K, Llovet JM.
  • Journal Title: J Hepatol 48 Pages: 858-879
• [Journal Article] Association between cigarette smoking and chronic kidney disease in Japanese men. (2008)
  • Author(s): Ishizaka N, Ishizaka Y, Toda E, Shimomura H, Koike K, Seki G, Nagai R, Yamakado M.
  • Journal Title: Hypertens Res 31 Pages: 485-92
• [Journal Article] Relationship between Albuminuria, Low eGFR, and Carotid Atherosclerosis in Japanese Women. (2008)
  • Author(s): Ishizaka Y, Ishizaka N, Tani M, Toda A, Toda EI, Koike K, Yamakado M.
  • Journal Title: Kidney Blood Press Res 31 Pages: 164-170
• [Journal Article] Association between hepatitis B/C viral infection, chronic kidney disease and insulin resistance in individuals undergoing general health screening. (2008)
  • Author(s): Ishizaka N, Ishizaka Y, Seki G, Nagai R, Yamakado M, Koike K.
  • Journal Title: Hepatol Res 38 Pages: 775-783
• [Journal Article] MicroRNA122 is a key regulator of α-fetoprotein expression and biologically aggressive behavior of hepatocellular carcinoma.
  • Author(s): Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K.
  • Journal Title: Nat Commun in press
• [Patent(Industrial Property Rights)] 肝細胞癌発生予測因子としての血中ADAMTS13 (2010)
  • Inventor(s): 池田均、矢冨裕、建石良介、小池和彦、小野智子
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 12B10Y001-1
  • Filing Date: 2010-11-11