Immunologic response to Helicobacter involved in the development of chronic gastritis

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390207
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: WATANABE Norihiko Kyoto University, 医学研究科, 准教授 (50419446)
• Project Period (FY): 2008 – 2010
• Keywords: 内科学 / 免疫学 / 細胞・組織 / 生体分子 / 感染症

Research Abstract

H. pylori CagA in the stomach plays an important role in the migration of H. pylori-primed CM4^+ T cells in the gastric mucosa from the Peyer's patches. In addition, H. pylori CagA can directly trigger epithelial cells to produce TSLP and TSLP-mediated DC activation may be involved in Th2 responses triggering B cell activation in H. pylori-induced gastritis.

Research Products

• [Journal Article] Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice. (2011)
  • Author(s): Aoki N, Kido M, Iwamoto S, Nishiura H, Maruoka R, Tanaka J, Watanabe T, Okazaki T, Chiba T, Watanabe N.
  • Journal Title: Gastroenterology. 140 Pages: 1322-1333
  • Peer Reviewed
• [Journal Article] Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses. (2010)
  • Author(s): Kido M, Tanaka J, Aoki N, Iwamoto S, Nishiura H, Chiba T, Watanabe N.
  • Journal Title: Infect Immun. 78 Pages: 108-114
  • Peer Reviewed
• [Journal Article] Proinflammatory Th2 cytokines induce production of thymic stromal lymphopoietin in human colonic epithelial cells. (2010)
  • Author(s): Tanaka J, Saga K, Kido M, Nishiura H, Akamatsu T, Chiba T, Watanabe N.
  • Journal Title: Dig Dis Sci. 55 Pages: 1896-1904
  • Peer Reviewed
• [Journal Article] Distinct signal codes generate dendritic cell functional plasticity. (2010)
  • Author(s): Arima K, Watanabe N, Hanabuchi S, Chang M, Sun SC, Liu YJ.
  • Journal Title: Sci Signal. 3(105) Pages: ra4
  • Peer Reviewed
• [Journal Article] Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of forkhead box P3+ regulatory T cells in human thymus. (2010)
  • Author(s): Hanabuchi S, Ito T, Park WR, Watanabe N, Shaw JL Roman E, Arima K, Wang YH, VooKS, Cao W, Liu YJ.
  • Journal Title: J Immunol. 184 Pages: 2999-3007
  • Peer Reviewed
• [Journal Article] Analysis of Humoral Immune Response in Experimental Autoimmune Pancreatitis in Mice. (2010)
  • Author(s): Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K, Kido M, Watanabe N, Uchida K, Fukui T, Okazaki K, Chiba T.
  • Journal Title: Pancreas. 39 Pages: 224-231
  • Peer Reviewed
• [Journal Article] Human TSLP and TLR3 ligand promote differentiation of Th17 cells with central memory phenotype under Th2- polarizing conditions. (2009)
  • Author(s): Tanaka J, Watanabe N, Kido M, Saga K, Akamatsu T, Nishio A, Chiba T
  • Journal Title: Clin Exp Allergy. 39 Pages: 89-100
  • Peer Reviewed
• [Journal Article] Human TSLP directly enhances expansion of CD8+ T cells. (2008)
  • Author(s): Akamatsu T, Watanabe N, Kido M, Saga K, Tanaka J, Kuzushima K, Nishio A, Chiba T.
  • Journal Title: Clin Exp Immunol. 154 Pages: 98-106
  • Peer Reviewed
• [Journal Article] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling. (2008)
  • Author(s): Kido M, Watanabe N, Okazaki T, Akamatsu T, Tanaka J, Saga K, Nishio A, Honjo T, Chiba T.
  • Journal Title: Gastroenterology. 135 Pages: 1333-1343
  • Peer Reviewed
• [Journal Article] Mechanism for gastric cancer development by Helicobacter pylori infection. (2008)
  • Author(s): Chiba T, Marusawa H, Seno H, Watanabe N.
  • Journal Title: J Gatroenterol Hepatol 23 Pages: 1175-1181
• [Presentation] Differential roles of PD-1 mediated signaling in inflammation in mouse models of Helicobacter infection and autoimmune gastritis. (2010)
  • Author(s): 木戸政博, 岩本諭, 青木信裕, 西浦尚代, 田中淳也, 千葉勉, 渡部則彦
  • Organizer: 第16回日本ヘリコバクター学会学術集会
  • Place of Presentation: 京都大学医学部芝蘭会館
  • Year and Date: 2010-06-24
• [Presentation] Regulatory T cells and PD-1-mediated signaling in AIH. (2010)
  • Author(s): 渡部則彦
  • Organizer: International Forum of the 96^<th> Annual Meeting of the Japanese Society of Gastroenterology
  • Place of Presentation: 新潟県新潟市朱鷺メッセ
  • Year and Date: 2010-04-24
• [Presentation] Regulatory roles of PD1 mediated signaling in the development of Helicobacter-induced gastritis and autoimmune gastritis (2009)
  • Author(s): 青木信裕、渡部則彦、千葉勉
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-04
• [Presentation] TSLP regulates autoantibody production and inflammation in mouse models of autoimmune gastritis. (2009)
  • Author(s): 西浦尚代、渡部則彦、千葉勉
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-04
• [Presentation] Proinflammatory Th2 cytokines induce production of thymic stromal lymphopoietin in human colonic epithelial cells. (2009)
  • Author(s): 田中淳也、渡部則彦、千葉勉
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-02
• [Presentation] Role of Peyer's patches in H. pylori immunity. (2009)
  • Author(s): 渡部則彦
  • Organizer: XXIst International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
  • Place of Presentation: Fundacao Eng.Antonio de Almeida, Porto, Portugal
  • Year and Date: 2009-09-18
• [Presentation] Helicobacter promote gastric epithelial cells to produce TSLP and induce DC-mediated inflammatory Th2 responses. (2009)
  • Author(s): Watanabe N, Kido M, Tanaka J, Chiba T.
  • Organizer: 米国消化器病週間(DDW)2009会議
  • Place of Presentation: Mccormick Place Convention Center, Chicago, USA.
  • Year and Date: 2009-06-02
• [Presentation] Helicobacter pylori感染に対する宿主免疫応答でのTSLPの役割 (2008)
  • Author(s): 木戸政博、渡部則彦、千葉勉
  • Organizer: 第45回日本消化器免疫学会総会
  • Place of Presentation: 京都市京都メルパルク
  • Year and Date: 2008-07-03
• [Presentation] Helicobacter pylori感染に対する宿主免疫応答でのTSLPの役割 (2008)
  • Author(s): 木戸政博、渡部則彦、千葉勉
  • Organizer: 第14回日本ヘリコバクター学会学術集会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2008-06-27
• [Presentation] Helicobacter pylori感染に対する宿主免疫応答でのTSLPの役割 (2008)
  • Author(s): 木戸政博、渡部則彦、千葉勉
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-05-10
• [Book] H.pylori infection .The route from inflammation to cancer. In Sansonetti P, ed, Infection Biology Handbook Series. Bacterial Virulence. (2010)
  • Author(s): Chiba T, Marusawa H, Seno H, Watanabe N
  • Total Pages: 31-41
  • Publisher: Basic principles, models and global approaches. Willey-Blackwell