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2010 Fiscal Year Final Research Report

レチノイン酸応答性の新規機能性RNAの同定による肝細胞癌の診療への応用

Research Project

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Project/Area Number 20390209
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTottori University

Principal Investigator

SHIOTA Goshi  Tottori University, 大学院・医学系研究科, 教授 (70263457)

Co-Investigator(Kenkyū-buntansha) KURIMASA Akihiro  鳥取大学, 大学院・医学系研究科, 准教授 (80343276)
HOSHIKAWA Yoshiko  鳥取大学, 大学院・医学系研究科, 助教 (10181489)
Project Period (FY) 2008 – 2010
Keywordsレチノイン酸 / 応答遺伝子 / インシリコ解析 / 肝細胞癌診療
Research Abstract

It is important to clarify the mechanisms by which retinoid signaling prevents the hepatocarcinogenesis in detail. In the present study, genome-wide analysis of the downstream genes controlled by RA signaling was done by means of in silico and in vitro screenings. First, the in silico approach was used to pick up rnaClusters with RA responsive element (RARE) in their upstream regions, providing 201 rnaClusters (hereafter referred to as Target RNA of Retinoic Acid, TRRA). One hundred eleven of those TRRAs were known as Refseq Genes while the others were unknown naClusters. Next,we screened 201 TRRAs with chromatin immunoprecipitation and quantitative RT-PCR. As a result, it was suggested that the expression of 27 TRRAs was regulated through ATRA-dependent recruitment of retinoic acid eceptors to their RAREs. These twenty-seven TRRAs identified in this study may be useful targets of liver cancer treatment.

  • Research Products

    (6 results)

All 2010

All Presentation (5 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] レチノイン酸応答性遺伝子の同定による肝癌知慮y標的の探索2010

    • Author(s)
      上田知沙、明地雄司、土谷博之、汐田剛史
    • Organizer
      日本レチノイド研究会第21回学術集会
    • Place of Presentation
      大阪、大阪医科大学
    • Year and Date
      20101113-20101114
  • [Presentation] レチノイン酸標的遺伝子の探索による肝癌治療標的の同定2010

    • Author(s)
      上田知沙、明地雄司、土谷博之、汐田剛史
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      20101013-20101014
  • [Presentation] レチノイン酸受容体応答性遺伝子の探索2010

    • Author(s)
      上田知沙、明地雄司、土谷博之、星川淑子、汐田剛史
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田市、秋田アトリオン
    • Year and Date
      20100618-20100619
  • [Presentation] レチノイド標的遺伝子の同定による肝癌の新規治療法開発2010

    • Author(s)
      明地雄司、上田知沙、土谷博之、汐田剛史
    • Organizer
      第46回日本肝臓学会
    • Place of Presentation
      山形市、ホテルメトロポリタン山形
    • Year and Date
      20100527-20100528
  • [Presentation] Systematic idesntification of novel cancer targets mediating anticancerous effects of retinoic acids2010

    • Author(s)
      Shiota G
    • Organizer
      Yonsei-Tottori Joint Symposium on the future of Medicine
    • Place of Presentation
      韓国、延世大学高原州医科大学
    • Year and Date
      2010-10-18
  • [Patent(Industrial Property Rights)] レチノイン酸受容体リガンドの抗腫瘍作用、発癌抑制を含めた種々の作用を決定する遺伝子の同定2010

    • Inventor(s)
      汐田剛史、明地雄司、上田知沙、土谷博之
    • Industrial Property Rights Holder
      汐田剛史、明地雄司、上田知沙、土谷博之
    • Industrial Property Number
      特願,2010-093226
    • Filing Date
      2010-04-14

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Published: 2012-01-26   Modified: 2016-04-21  

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