2010 Fiscal Year Final Research Report
Clarification of the mechanism of metabolic and vascular regulation by RAMP and its application in metabolic disorders and vascular injuries.
| Project/Area Number |
20390221
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
SHINDO Takayuki Shinshu University, 医学系研究科, 教授 (90345215)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Takayuki 信州大学, 医学系研究科, 准教授 (80317825)
SHIMOZAWA Tatsuo 東京大学, 医学部附属病院, 講師 (90231365)
MURATA Toshinori 信州大学, 医学部, 教授 (50253406)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アドレノメデュリン / RAMP / 血管 / 動脈硬化 / メタボリックシンドローム |
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| Research Abstract |
Recently, various humoral factors have attracted much attention in terms of being a common molecular basis that links the onset of metabolic syndrome with that of vascular complications. These factors play important roles in the maintenance of metabolic and vascular homeostasis. In contrast, an imbalance between the factors may cause the onset of metabolic syndrome and cardiovascular diseases.
Adrenomedullin (AM), originally identified as a potent vasodilatory peptide produced by vascular cells, has been shown to be synthesized by a variety of cell types and possesses various biological functions. AM has been shown to be involved in both metabolic and vascular homeostasis.
In this study, by using gene-engineered mice of RAMP2 (a receptor activity-modifying protein of AM' s receptor), we proved that RAMP2 is the key molecule of the AM' s metabolic and vascular regulation. RAMP2 could be a novel therapeutic target for metabolic syndrome and cardiovascular diseases.
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Research Products
(19 results)
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[Journal Article] Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver.2010
Author(s)
Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T.
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Journal Title
Peptides. 31(5)
Pages: 865-871
Peer Reviewed
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[Journal Article] GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.2008
Author(s)
Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T.
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Journal Title
J Clin Invest. 118
Pages: 29-39
Peer Reviewed
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[Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.2008
Author(s)
Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
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Journal Title
J Biol Chem. 283(36)
Pages: 24682-24689
Peer Reviewed
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