2010 Fiscal Year Final Research Report
Development of cell, gene and drug delivery system to the cardiovascular tissue using a novel cell-surface lectin.
| Project/Area Number |
20390222
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
IKEDA Uichi Shinshu University, 医学系研究科, 教授 (30221063)
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| Co-Investigator(Kenkyū-buntansha) |
KOYAMA Jun 信州大学, 医学系研究科, 准教授 (10303463)
IZAWA Atsushi 信州大学, 医学系研究科, 助教 (50464095)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 再生医療 / 糖鎖 / 遺伝子 / 心筋梗塞 / 動脈硬化 |
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| Research Abstract |
We found a novel function of vimentin and desmin of cardiovascular tissues by which these proteins interact with physiological GlcNAc-bearing ligands on the cell surface through their GlcNAc-binding lectin-like properties. Cell surface coating of bone marrow cells with GlcNAc promoted adhesion of these cells to cardiac myocytes and their regeneration to cardiac myocytes, and this would be useful for the treatment of cardiovascular disease with bone marrow implantation.
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[Journal Article] Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury.2011
Author(s)
Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
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Journal Title
Circulation 123
Pages: 594-604
Peer Reviewed
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[Journal Article] Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases.2009
Author(s)
Takahashi M, Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Horie T, Aizawa Y, Amano J, Minota S, Murohara T, Matsubara H, Ikeda U.
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Journal Title
Curr Pharm Design 15
Pages: 2778-2783
Peer Reviewed
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[Journal Article] Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation.2009
Author(s)
Doi H, Iso T, Shiba Y, Sato H, Yamazaki M, Oyama Y, Akiyama H, Tanaka T, Tomita T, Arai M, Takahashi M, Ikeda U, Kurabayashi M.
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Journal Title
Biochem Biophys Res Commun 381
Pages: 654-659
Peer Reviewed
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[Journal Article] Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat.2009
Author(s)
Nomoto T, Okada T, Shimazaki K, Yoshioka T, Nonaka-Sarukawa M, Ito T, Takeuchi K, Katsura KI, Mizukami H, Kume A, Ookawara S, Ikeda U, Katayama Y, Ozawa K.
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Journal Title
Gene Ther 16
Pages: 383-391
Peer Reviewed
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