2010 Fiscal Year Final Research Report
Host factors affecting human illness with avian and human A influenza viruses
| Project/Area Number |
20390233
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
KEICHO Naoto Research Institute, International Medical Center of Japan, 呼吸器疾患研究部, 部長 (80332386)
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| Co-Investigator(Kenkyū-buntansha) |
HIJIKATA Minako 独立行政法人国立国際医療研究センター研究所, 呼吸器疾患研究部, ウイルス性呼吸器疾患研究室長 (90332387)
SAKURADA Shinsaku 独立行政法人国立国際医療研究センター研究所, 呼吸器疾患研究部, 細菌性呼吸器疾患研究室長 (50178620)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 呼吸器感染症 |
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| Research Abstract |
The aim of the study was to elucidate host factors affecting illness with avian and human influenza A viruses. Expression of glycosyltransferase genes related to the synthesis of influenza virus receptors and antiviral genes was analyzed in human bronchial epithelial cells. A sialyltransferase gene expression was upregulated by an inflammatory stimulus. Expression of antiviral MxA gene in airway epithelial cells was related to genetic polymorphisms in the promoter region.
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