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2010 Fiscal Year Self-evaluation Report

Roles of ER stress in renal pathophysiology and development of novel

Research Project

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Project/Area Number 20390235
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Yamanashi

Principal Investigator

KITAMURA Masanori  University of Yamanashi, 大学院・医学工学総合研究部, 教授 (90333062)

Project Period (FY) 2008 – 2012
Keywords胞体ストレス / 炎症 / シグナル伝達 / 腎臓病学
Research Abstract

近年、多彩な疾患群の発症・進展過程において、小胞体ストレスがその病因として注目されてきた。しかし腎臓病学の分野では、小胞体ストレスの病理学的意義・重要性に関し、未だほとんど検討がなされていない。本研究は、各種腎病変における小胞体ストレスの関与・役割をlight side, dark sideの両面から明らかにするとともに、そこに関与する小胞体ストレス応答の分子機構を解明し、さらにその知見を基盤に、小胞体ストレス応答を標的とした新たな腎疾患治療戦略を創出することを目的とする。具体的には以下のタイムテーブルのもと、研究を推進する。

  • Research Products

    (14 results)

All 2011 2010 2009 2008

All Journal Article (5 results) Presentation (5 results) Book (4 results)

  • [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR : involvement of C/EBPβand mTOR-dependent dephosphorylation of Akt.2011

    • Author(s)
      Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Kato H, Huang T, Yao J Paton AW, Paton JC, Kitamura M
    • Journal Title

      Mol Cell Biol 31

      Pages: 1710-1718

  • [Journal Article] ER stress depresses NF-κB activation in mesangial cells through preferential induction of C/EBPβ.2010

    • Author(s)
      Hayakawa K, Nakajima S, Hiramatsu N, Okamura M, Huang T, Saito Y, Tagawa Y, Tamai M, Takahashi S, YaoJ, Kitamura M
    • Journal Title

      J Am Soc Nephrol 21

      Pages: 73-81

  • [Journal Article] A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response.2009

    • Author(s)
      Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A
    • Journal Title

      J Immunol 183

      Pages: 1368-1374

  • [Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family : Implication for unfolded protein response.2009

    • Author(s)
      Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, Paton AW, Paton JC, Kitamura M
    • Journal Title

      J Immunol 182

      Pages: 7201-7211

  • [Journal Article] Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response : A mechanism for subsidence of inflammation.2009

    • Author(s)
      Hayakawa K, Hiramatsu N, Okamura M, Yamazaki H, Nakajima S, YaoJ, Paton AW, Paton JC, Kitamura M
    • Journal Title

      J Immunol 182

      Pages: 1182-1191

  • [Presentation] Anti-inflammatory potential of subtilase cytotoxin : Dual suppression of NF-κB via induction of C/EBPβand mTOR-mediated dephosphorylation of Akt.2010

    • Author(s)
      Nakajima S, Huang T, Yao J, Kitamura M
    • Organizer
      43rd Annual Meeting of The American Society of Nephrology.
    • Place of Presentation
      Denver
    • Year and Date
      20101116-20101121
  • [Presentation] Subtilase cytotoxin suppresses TNF-α-induced activation of NF-κB via induction of C/EBPβand suppression of Akt.2009

    • Author(s)
      Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Huang T, Yao J, Kitamura M
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-08
  • [Presentation] Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrccarbons.2008

    • Author(s)
      Kitanmra M, Kasai A, Hiramatsu N, Hayakawa K, Yao J
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20081210-20081212
  • [Presentation] Suppression of NF-κB by cyclosporine A and tacroLimus (FK506) via induction of the C/EBP family : Implication for unfold protein response response.2008

    • Author(s)
      Hayakawa K, Du S, Hiramatsu N, Kasai A, Okamura M, Huang T,Yao J, Sawada N, Takeda M, Kitamura M
    • Organizer
      第31回日本分子生物学会年会/第82回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20081210-20081212
  • [Presentation] Suppression of NF-icB by cyclosporine A and tacrolimus(FK506)via inducrion of the GEB family : Implication for unfolded protein response.2008

    • Author(s)
      Kitamura M, Du S, Hiramatsu N, Hayakawa K, Okamura M, Huang T, Yao J, Takeda M
    • Organizer
      41st Annual Meeting of The American Society of Nephrology.
    • Place of Presentation
      Philadelphia
    • Year and Date
      20081104-20081109
  • [Book] Methods in Enzymology(UPR and Cell Stress)(Real-time monitoring of ER stress in living cells and animals using ESTRAP assay)(Vol.490, Chaoter 5)2011

    • Author(s)
      Kitamura M, Hiramatsu N
    • Total Pages
      93-106
  • [Book] Annual Review腎臓(小胞体ストレストメサンギウムの細胞応答)2011

    • Author(s)
      北村正敬
    • Total Pages
      30-37
  • [Book] Annual Review腎臓(Gap Junctionを介した細胞間情報伝達メサンギウム細胞の動態制御に於ける役割)2009

    • Author(s)
      姚建、北村正敬
    • Total Pages
      14-19
  • [Book] Annual Review腎臓(腎における小胞体ストレス(ER stress)の意義2008

    • Author(s)
      北村正敬
    • Total Pages
      22-30

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Published: 2012-02-13   Modified: 2016-04-21  

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