2012 Fiscal Year Final Research Report
Roles of ER stress in renal pathophysiology and development of novel therapeutic approaches to kidney diseases
Project/Area Number |
20390235
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | University of Yamanashi |
Principal Investigator |
KITAMURA Masanori 山梨大学, 大学院・医学工学総合研究部, 教授 (90333062)
|
Co-Investigator(Kenkyū-buntansha) |
YAO Jian 山梨大学, 大学院・医学工学総合研究部, 准教授 (50303128)
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Project Period (FY) |
2008 – 2012
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Keywords | 小胞体ストレス / シグナル伝達 / 腎疾患 / 炎症 / アポトーシス |
Research Abstract |
The unfolded protein response (UPR) has two different faces; an anti-inflammatory aspect (light side) and tissue damaging potential (dark side). Different branches of the UPR contribute to the dark and light sides following endoplasmic reticulum (ER) stress. By modulating selective arms of the UPR, it is feasible to attenuate inflammation and to inhibit tissue damage caused by ER stress. 3’-Deoxyadenosineand 4-phenylbutyric acid analogues may be potentially useful for the treatment of ER stress-related disorders.
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[Journal Article] Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMPK2011
Author(s)
Chi Y, Li K, Yan Q, Koizumi S, Shi L, Takahashi S, Zhu Y, Matsue H, Takeda M, Kitamura M, Yao J
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Journal Title
J Pharmacol Exp Ther
Volume: 339
Pages: 257-266
DOI
Peer Reviewed
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[Journal Article] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion- triggered PERK - eIF2αpathway2011
Author(s)
Tagawa Y, Hiramatsu N, Kato H, Sakoh T, Nakajima S, Hayakawa K, Saito Y, Johno H, Takahashi S, Gu L, Yao J, and Kitamura M
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Journal Title
Toxicology
Volume: 287
Pages: 105-112
DOI
Peer Reviewed
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[Journal Article] Selective deletion of adipocytes, but not preadipocytes, by TNF-α via C/EBP- and PPARγ-mediated suppression of NF-κB2010
Author(s)
Tamai M, Shimada T, Hiramatsu N, Hayakawa K, Okamura M, Tagawa Y, Takahashi S, Nakajima S, Yao J, and Kitamura M
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Journal Title
Lab Invest
Volume: 90
Pages: 1385-1395
DOI
Peer Reviewed
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[Journal Article] ER stress depresses NF-κB activation in mesangial cells through preferential induction of C/EBPβ2010
Author(s)
Hayakawa K, Nakajima S, Hiramatsu N, Okamura M, Huang T, Saito Y, Tagawa Y, Tamai M, Takahashi S, Yao J, and Kitamura M
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Journal Title
J Am Soc Nephrol
Volume: 21
Pages: 73-81
DOI
Peer Reviewed
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[Journal Article] Preferential blockade of dioxin-induced activation of the aryl hydrocarbon receptor by Antrodia camphorata2009
Author(s)
Mukai M, Hayakawa K, Okamura M, Tagawa Y, Nakajima S, Saito Y, Takahashi S, Yao J, Nishimura D, Sugi M, Matsunaga M, and Kitamura M
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Journal Title
Biol Pharm Bull32
Volume: 32
Pages: 1510-1515
URL
Peer Reviewed
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[Journal Article] Activation of the Akt - NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response2009
Author(s)
YamazakiH, Hiramatsu N, Hayakawa K, Tagawa Y, Okamura M, Ogata R, Huang T,Nakajima S, Yao J, Paton AW, Paton JC, andKitamura M
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Journal Title
J Immunol
Volume: 183
Pages: 1480-1487
DOI
Peer Reviewed
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[Journal Article] A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response2009
Author(s)
Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y,Ogawa H,Matsuoka S, Paton AW,Paton JC, Kitamura M,and Nakao A
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Journal Title
Immunol
Volume: 183
Pages: 1368-1374
DOI
Peer Reviewed
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[Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response2009
Author(s)
Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, Paton AW, Paton JC, and KitamuraM
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Journal Title
J Immunol
Volume: 182
Pages: 7201-7211
DOI
Peer Reviewed
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[Journal Article] Suppression of adipocyte differentiation by Cordyceps militaris through activation of the aryl hydrocarbon receptor.2008
Author(s)
Shimada T, Hiramatsu N, Kasai A, Mukai M, Okamura M, Yao J, Huang T, Tamai M, Takahashi S, Nakamura T, and Kitamura M
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Journal Title
Am J Physiol-Endocrinol and Metab
Volume: 295
Pages: E859-867
DOI
Peer Reviewed
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[Journal Article] T cell receptor-mediated signaling induces GRP78 expression in T cells : The implications in maintaining T cell viability2008
Author(s)
Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, and Nakao A
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Journal Title
Biochem Biophys Res Commun
Volume: 371
Pages: 762-766
DOI
Peer Reviewed
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[Journal Article] Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response2008
Author(s)
Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, Kasai A, Takano Y, Shitamura A, Shimada T, Yao J, and Kitamura M
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Journal Title
J Biol Chem
Volume: 283
Pages: 4252-4260
URL
Peer Reviewed
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