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2011 Fiscal Year Final Research Report

Development of risk assessment and prevention of cerebral amyloid angiopathy-related cerebral hemorrhages

Research Project

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Project/Area Number 20390242
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKanazawa University

Principal Investigator

YAMADA Masahito  金沢大学, 医学系, 教授 (80191336)

Co-Investigator(Kenkyū-buntansha) YOSHITA Mitsuhiro  金沢大学, 医学系, 協力研究員 (60361995)
Co-Investigator(Renkei-kenkyūsha) NAIKI Hironobu  福井大学, 医学部, 教授 (10227704)
Project Period (FY) 2008 – 2011
Keywords脳アミロイドアンギオパチー / アミロイド / 脳内出血 / MRI / PET / アミロイドβ蛋白 / 実験モデル / 天然フェノール化合物
Research Abstract

We investigated cerebral amyloid angiopathy(CAA) and CAA-related hemorrhages to develop methods of risk assessment and prevention. We propose a table of biomarkers and risk factors to predict future development of CAA-related hemorrhages and other disorders. We established an in vitro model of CAA. We revealed that natural phenolic compounds inhibited fibril formation and oligomerization of amyloidβ-protein(Aβ) in in vitro and in vivo models.

  • Research Products

    (17 results)

All 2011 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (2 results) Book (2 results)

  • [Journal Article] Effects of sex hormones on Alzheimer disease-associatedβ-amyloid oligomer formation in vitro2011

    • Author(s)
      Morinaga A, Ono K, Takasaki J, Ikeda T, Hirohata M, Yamada M
    • Journal Title

      Exp Neurol

      Volume: 228 Pages: 298-302

    • Peer Reviewed
  • [Journal Article] Vitamin A has antioligomerization effects on amyloidβ-protein in vitro2011

    • Author(s)
      Takasaki J-I, Ono K, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M
    • Journal Title

      J Alzheimers Dis

      Volume: 27 Pages: 271-280

    • Peer Reviewed
  • [Journal Article] Curcumin and Alzheimer's disease2010

    • Author(s)
      Hamaguchi T, Ono K, Yamada M
    • Journal Title

      CNS Neurosci Ther

      Volume: 16 Pages: 285-297

    • Peer Reviewed
  • [Journal Article] Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy2010

    • Author(s)
      Hirohata M, Yoshita M, Ishida C, Ikeda S-I, Tamaoka A, Kuzuhara S, Shoji M, Ando Y, Tokuda T, Yamada M
    • Journal Title

      Eur J Neurol

      Volume: 17 Pages: 823-829

    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid of Alzheimer patients promotes amyloidβ-protein oligomerization2010

    • Author(s)
      Ikeda T, Ono K, Elashoff D, Condron MM, Noguchi-Shinohara M, Yoshita M, Teplow DB, Yamada M
    • Journal Title

      J Alzheimers Dis

      Volume: 21 Pages: 81-86

    • Peer Reviewed
  • [Journal Article] Critical role of interfaces and agitation on the nucleation of Aβamyloid fibrils at low concentrations of Aβmonomers2010

    • Author(s)
      Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H
    • Journal Title

      Biochem Biophys Acta-Proteins and Proteomics

      Volume: 1804 Pages: 986-995

    • Peer Reviewed
  • [Journal Article] New therapeutic strategy for amyloidosis2009

    • Author(s)
      Morinaga A, Ono K, Yamada M
    • Journal Title

      Future Neurol

      Volume: 4 Pages: 287-289

    • Peer Reviewed
  • [Journal Article] Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloidβaggregation pathway2009

    • Author(s)
      Hamaguchi T, Ono K, Murase A, Yamada M
    • Journal Title

      Am J Pathol

      Volume: 175 Pages: 2557-2565

    • Peer Reviewed
  • [Journal Article] Editorial : Anti-amyloidogenic/protein-misfolding therapies in amyloidosis and other protein-misfolding disorders2008

    • Author(s)
      Yamada M
    • Journal Title

      Curr Pharm Design

      Volume: 14 Pages: 3203-3204

  • [Journal Article] Predicting cerebral amyloid angiopathy-realated intracerebral hemorrhages and other cerebrovascular disorders in Alzheimer's disease

    • Author(s)
      Yamada M
    • Journal Title

      Front Neurol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Cerebral amyloid anigopathy

    • Author(s)
      Yamada M, Naiki H
    • Journal Title

      Prog Mol Biol Transl Sci

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Phenolic compounds prevent amyloidβ-protein oligomerization and synaptic dysfunction by site specific binding

    • Author(s)
      Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J-I, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M
    • Journal Title

      J Biol Chem

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Multiple cerebral infarcts with a few vasculitic lesions in the chronic stage of cerebral amyloid angiopathy related inflammation

    • Author(s)
      Sakai K, Hayashi S, Sanpei K, Yamada M, Takahashi H
    • Journal Title

      Neuropathology

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] The effects of phenolic compounds on Aβaggregation and cerebal Aβplaques and angiopathy2010

    • Author(s)
      Yamada M, Hamaguchi T, Ono K, Hirohata M, Morinaga A, Ikeda T, Takasaki J, Murase A
    • Organizer
      2^<nd> International CAA Conference
    • Place of Presentation
      UCLA Medical Center(USA)
    • Year and Date
      2010-05-15
  • [Presentation] Cerebral Amyloid Angiopathy : Epidemiology, Clinical Features and Genetic Risk Factors2008

    • Author(s)
      Yamada M
    • Organizer
      The 11th International conference on Alzheimer's disease and Related Disorders
    • Place of Presentation
      McCormick Place(USA)
    • Year and Date
      2008-07-29
  • [Book] アミロイドーシスー診療のすべて:ガイドライン完全解説2011

    • Author(s)
      山田正仁
    • Publisher
      医歯薬出版
  • [Book] 脳アミロイドアンギオパチー2009

    • Author(s)
      山田正仁、石田千穂
    • Total Pages
      261-262
    • Publisher
      協和企画

URL: 

Published: 2013-07-31  

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