2011 Fiscal Year Final Research Report
Development of risk assessment and prevention of cerebral amyloid angiopathy-related cerebral hemorrhages
Project/Area Number |
20390242
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YOSHITA Mitsuhiro 金沢大学, 医学系, 協力研究員 (60361995)
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Co-Investigator(Renkei-kenkyūsha) |
NAIKI Hironobu 福井大学, 医学部, 教授 (10227704)
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Project Period (FY) |
2008 – 2011
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Keywords | 脳アミロイドアンギオパチー / アミロイド / 脳内出血 / MRI / PET / アミロイドβ蛋白 / 実験モデル / 天然フェノール化合物 |
Research Abstract |
We investigated cerebral amyloid angiopathy(CAA) and CAA-related hemorrhages to develop methods of risk assessment and prevention. We propose a table of biomarkers and risk factors to predict future development of CAA-related hemorrhages and other disorders. We established an in vitro model of CAA. We revealed that natural phenolic compounds inhibited fibril formation and oligomerization of amyloidβ-protein(Aβ) in in vitro and in vivo models.
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Research Products
(17 results)
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[Journal Article] Phenolic compounds prevent amyloidβ-protein oligomerization and synaptic dysfunction by site specific binding
Author(s)
Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J-I, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M
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Journal Title
J Biol Chem
Volume: (in press)
Peer Reviewed
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