2010 Fiscal Year Final Research Report
Role of Neuronal Network System in Development of the Metabolic Syndrome
| Project/Area Number |
20390252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
KATAGIRI Hideki Tohoku University, 大学院・医学系研究科, 教授 (00344664)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGAKI Yasushi 東北大学, 大学院・医学系研究科, 准教授 (50375002)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖尿病 / メタボリックシンドローム / 肥満 |
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| Research Abstract |
We have recently discovered that neuronal networks among organs/tissues play important roles in maintaining metabolic homeostasis in the whole body. In this study, we examined how the inter-organ neuronal networks contribute to the development of the metabolic syndrome. First, we found that hepatic ERK activation induced insulin hypersecretion and pancreatic beta cell proliferation. This liver-to-pancreas coordination is mediated by a novel neuronal network, consisting the splanchnic afferents and vagal efferents. Furthermore, this neuronal network is involved in obesity-induced hyperinsulinemia. In addition, we have found that another neuronal network originating in hepatic PPARgamma expression causes hypertension associated with obesity. Thus, this study has revealed the mechanisms underlying obesity-induced hyperinsulinemia and hypertension, which are major features of the metabolic syndrome. The mechanisms involve two types of inter-organ metabolic networks, which are potential therapeutic targets for the metabolic syndrome.
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[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity.2011
Author(s)
Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T.
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Journal Title
Am J Physiol Cell Physiol. In Press
Peer Reviewed
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[Journal Article] Molecular Characterization of the Tumor Suppressor Candidate 5 Gene : Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans.2010
Author(s)
Knotts TA, Lee HW, Kim JB, Oort PJ, McPherson R, Dent R, Tachibana K, Doi T, Yu S, Reddy JK, Uno K, Katagiri H, Pasarica M, Smith SR, Sears DD, Grino M, Adams SH.
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Journal Title
PPAR Research
Pages: 867678
Peer Reviewed
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[Journal Article] Characterization of a novel murine preadipocyte line, AP-18, isolated from subcutaneous tissue : analysis of adipocyte-related gene expressions.2010
Author(s)
Chen C, Takahashi K, Yoshida A, Takizawa Y, Lee Y, Nakui M, Doi H, Takebayashi Y, Fukumoto M, Yamada T, Katagiri H, Oka Y, Satoh J.
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Journal Title
Cell Biol Int 34(3)
Pages: 293-299
Peer Reviewed
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[Journal Article] Pinl associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.2010
Author(s)
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T.
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Journal Title
J Biol Chem 285(43)
Pages: 33018-33027
Peer Reviewed
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[Journal Article]2009
Author(s)
Tokita A, Ishigaki Y, Okimoto H, Hasegawa H, Koiwa Y, Kato M, Ishihara H, Hinokio Y, Katagiri H, Kanai H, Oka Y.
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Journal Title
Atherosclerosis 206(1)
Pages: 168-172
Peer Reviewed
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[Journal Article] Peginterferon (PEG-IFN) plus Ribavirin Combination Therapy, but neither Interferon nor PGE-IFN Alone, Apparently Induced Type 1 Diabetes in a Patient with Chronic Hepatitis C.2009
Author(s)
Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y.
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Journal Title
Internal Medicine 48
Pages: 1387-1390
Peer Reviewed
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[Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.2009
Author(s)
Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Oike Y.
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Journal Title
Cell Metab 10
Pages: 178-188
Peer Reviewed
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[Journal Article] Impact of Plasma Oxidized LDL Removal on Atherosclerosis.2008
Author(s)
Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y.
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Journal Title
Circulation 118
Pages: 75-83
Peer Reviewed
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[Journal Article] Regulation of Pancreatic β cell Mass by Neuronal Signals from the Liver.2008
Author(s)
Imai J, Katagiri H, Yamada Y, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y.
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Journal Title
Science 322
Pages: 1250-1254
Peer Reviewed
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