2010 Fiscal Year Final Research Report
Molecular machinery of granule exocytosis in pancreatic α and β cells
| Project/Area Number |
20390253
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
IZUMI Tetsuro Gunma University, 生体調節研究所, 教授 (00212952)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 遺伝子 / 細胞・組織 / 生理学 / 蛋白質 / 糖尿病 |
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| Research Abstract |
We have analyzed the functional significance of lipid and protein interactions involving the Rab27a effector, granuphilin, in both cultured cells and genetically engineered mice. We have also found that another Rab27a effector, exophilin8, transiently traps insulin granules into the cortical actin network close to the microtubule plus-ends and supplies them for release during the stimulation. Finally, using a proteomics approach, we have systemically identified Rab27a-interacting molecules in both α and β cells.
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[Journal Article] Involvement of Vps33a in the fusion of uroplakin-degrading multivesicular bodies with lysosomes.2009
Author(s)
Guo X, Tu L, Gumper I, Plesken H, Novak EK, Chintala S, Swank RT, Pastores G, Torres P, Izumi T, Sun T-T, Sabatini DD, Kreibich G
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Journal Title
Traffic 10
Pages: 1350-1361
Peer Reviewed
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