2010 Fiscal Year Final Research Report
The role of vaspin in metabolic syndrome
Project/Area Number |
20390257
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Okayama University |
Principal Investigator |
WADA Jun Okayama University, 大学院・医歯薬学総合研究科, 准教授 (30294408)
|
Co-Investigator(Kenkyū-buntansha) |
MAKINO Hirofumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50165685)
|
Project Period (FY) |
2008 – 2010
|
Keywords | メタボリックシンドローム / インスリン抵抗性 / アディポカイン / バスピン / 糖尿病 / 脂質異常症 / 高血圧 / 肥満症 |
Research Abstract |
Vaspin is a novel adipocytokine, which was identified from visceral adipose tissues in obese rats. The injection of recombinant vaspin into obese mice and experiments using vaspin transgenic and knockout mice revealed that vaspin is a compensatory factor for insulin resistance in metabolic syndrome. Vaspin circulated in the sera of human subjects and it positively correlated with body mass index and degree of insulin resistance. Serum levels of vaspin were higher in patients with type 2 diabetes compared with normal healthy subjects. The regulation of serum concentration of vaspin differed from leptin and adiponectin and vaspin may be a new therapeutic target for metabolic syndrome.
|
-
-
-
[Journal Article] In vivo delivery of gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7.2010
Author(s)
Zhang Q, Shi Y, Wada J, Malakauskas SM, Liu M, Ren Y, Du C, Duan H, Li Y, Li Y, Zhang Y
-
Journal Title
PLoS ONE 5(7)
Pages: e11709
Peer Reviewed
-
[Journal Article] Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.2010
Author(s)
Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Masuzaki H, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Nakamura Y, Kamatani N
-
Journal Title
J Hum Genet 55(11)
Pages: 738-742
Peer Reviewed
-
[Journal Article] Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome.2009
Author(s)
Hotta K, Nakamura T, Takasaki J, Takahashi H, Takahashi A, Nakata Y, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y
-
Journal Title
J Hum Genet 54(4)
Pages: 230-235
Peer Reviewed
-
[Journal Article] Enhanced interaction between focal adhesion and adherens junction proteins : involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement.2009
Author(s)
Sun X, Shikata Y, Wang L, Ohmori K, Watanabe N, Wada J, Shikata K, Birukov KG, Makino H, Jacobson JR, Dudek SM, Garcia JG
-
Journal Title
Microvasc Res 77(3)
Pages: 304-313
Peer Reviewed
-
[Journal Article] Endothelial barrier protection by FTY720 under hyperglycemic condition : involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.2009
Author(s)
Sarai K, Shikata K, Shikata Y, Omori K, Watanabe N, Sasaki M, Nishishita S, Wada J, Goda N, Kataoka N, Makino H
-
Journal Title
Am J Physiol Cell Physiol 297(4)
Pages: C945-954
Peer Reviewed
-
[Journal Article] Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.2009
Author(s)
Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y
-
Journal Title
J Hum Genet 54(12)
Pages: 727-731
Peer Reviewed
-
[Journal Article] Procollagen C-proteinase enhancer-1 (PCPE-1) interacts with beta(2)-microglobulin (beta2-m) and may help initiate beta2-m amyloid fibril formation in connective tissues.2008
Author(s)
Morimoto H, Wada J, Font B, Mott JD, Hulmes DJ, Ookoshi T, Naiki H, Yasuhara A, Nakatsuka A, Fukuoka K, Takatori Y, Ichikawa H, Akagi S, Nakao K, Makino H
-
Journal Title
Matrix Biol 27(3)
Pages: 211-219
Peer Reviewed
-
-
-
-
[Journal Article] Variations in the FTO gene are associated with severe obesity in the Japanese.2008
Author(s)
Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yondeda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y
-
Journal Title
J Hum Genet 53(6)
Pages: 546-553
Peer Reviewed
-
[Journal Article] INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.2008
Author(s)
Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y
-
Journal Title
J Hum Genet 53(9)
Pages: 857-862
Peer Reviewed
-
[Journal Article] Collectrin is involved in the development of salt-sensitive hypertension by facilitating the membrane trafficking of apical membrane proteins via interaction with SNARE complex.2008
Author(s)
Yasuhara A, Wada J, Malakauskas SM, Zhang Y, Eguchi J, Nakatsuka A, Murakami K, Kanzaki M, Teshigawara S, Yamagata K, Le TH, Makino H
-
Journal Title
Circulation 118
Pages: 2146-2155
Peer Reviewed
-
-
-
-