2010 Fiscal Year Final Research Report
Elucidation of the molecular mechanisms underlying insulin resistance and metabolic disorders using a proteomics technology
| Project/Area Number |
20390258
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
ASANO Tomoichiro Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (70242063)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAMATA Hideaki 広島大学, 大学院・医歯薬学総合研究科, 准教授 (10233925)
NAKATSU Yusuke 広島大学, 大学院・医歯薬学総合研究科, 助教 (20452584)
SAKODA Hideyuki 東京大学, 大学病院, 助教 (50376464)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | インスリン / 代謝 / シグナル伝達 / プロテオミクス / 糖取り込み / 糖尿病 |
|---|
| Research Abstract |
Insulin exerts its metabolic actions through many signal transduction proteins and transcription factor. In this study, we carried out the screening the binding proteins with the important proteins for the metabolic regulation or insulin action. As a result, we identified Pinl to regulate IRS-1 phosphorylation as well as the subcellular distribution of Crtc2. Besides Pinl, several important protein associations were identified, which would be useful for the development of a novel drug to treat diabetes mellitus.
|
-
-
-
[Journal Article] Nuclear IKKβ is an adaptor protein for IκBα ubiquitination and degradation in UV-induced NF-κB activation.2010
Author(s)
Tsuchiya, Y., Asano, T., Nakayama, K., Kato, T., Karin, M., Kamata, H.
-
Journal Title
Molecular Cell 39(4)
Pages: 570-82
Peer Reviewed
-
-
[Journal Article] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.2010
Author(s)
Kawamura, Y., Uchijima, Y., Horike, N., Tonami, K., Nishiyama, K., Amano, T., Asano, T., Kurihara, Y., Kurihara, H.
-
Journal Title
J.Clin.Invest. 120
Pages: 2817-28
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
