2011 Fiscal Year Final Research Report
Imaging analysis of impaired insulin exocytosis in type2 diabetes mellitus
| Project/Area Number |
20390260
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAIZUMI Mica (IMAIZUMI OHARA Mica) 杏林大学, 医学部, 准教授 (40201941)
AOYAGI Kyota 杏林大学, 医学部, 助教 (50453527)
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| Project Period (FY) |
2008 – 2011
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| Keywords | エネルギー / 糖代謝異常 |
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| Research Abstract |
It is becoming apparent that beta cell dysfunction observed in impaired insulin release is the essential element in the progression of diabetic patients. There are at least two populations of insulin secretory granules in beta cell, the RRP that is responsible for the initial(first phase) insulin release and a second reserve pool that is responsible for a more prolonged(second phase) insulin release. For now, it is still determined how these two types of insulin granules are involved in impaired insulin release In this study, we obtained the following results. 1) PDK1-Akt signaling pathway in beta cell mediated the potentiation of insulin release in the second phase. Akt signals seem to be involved in myosin Va-mediated actin network ; 2) Galpha o inactivation enhances insulin release. 3) CDKAL1, controls 1st phase insulin release.
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[Journal Article] Deletion of CDKAL1 Affects First-phase Glucose-stimulated Insulin Exocytosis2010
Author(s)
Ohara-Imaizumi M., Yoshida M. Aoyagi K, Saito T, Okamura T, Takenaka H, Akimoto Y, Nakamichi Y, Takanashi-Yanobu R, Nishiwaki C, Kawakami H, Kato N, Hisanaga S, Kakei M, and Nagamatsu S.
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Journal Title
PLoS One
Volume: 5
Pages: e15553
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[Journal Article] G・o represses insulin secretion by reducing vesicular docking in pancreatic ss cells2010
Author(s)
Zhao A, Ohara-Imaizumi M, Brissova M, Benninger RK, Xu Y, Hao Y, Abramowitz J, Boulay G, Powers A C, Piston D, Jiang M, Nagamatsu S, Birnbaumer L and Gu G.
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Journal Title
Diabetes
Volume: 59
Pages: 2522-2529
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[Journal Article] Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment2008
Author(s)
Kawai J, Ohara-Imaizumi M, Nakamichi Y, Okamura T, Akimoto Y, Matsushima S, Aoyagi K, Kawakami H, Watanabe T, Watada H, Kawamori R & Nagamatsu S.
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Journal Title
Biochem J
Volume: 412
Pages: 93-101
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[Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration2008
Author(s)
Okamoto M, Ohara-Imaizumi M, Kubota N, Hashimoto S, Eto K, Kanno T, Kubota T, Wakui M, Nagai R, Noda M, Nagamatsu S & Kadowaki T
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Journal Title
Diabetologia
Volume: 51
Pages: 827-835
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