2010 Fiscal Year Final Research Report
Basic and clinical research on the significance of androgen as the basis for the onset background of lifestyle-related diseases
| Project/Area Number |
20390263
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyushu University |
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Principal Investigator |
YANASE TOSHIHIKO Kyushu University, 医学部, 教授 (30239818)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Tomoko 福岡大学, 医学部, 助教 (10380528)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アンドロゲン / 動脈硬化 / メタボリックシンドローム / 選択的アンドロゲン受容 / 体修飾剤 |
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| Research Abstract |
As a mechanism for the anti-obesity effect of androgen, we clarified that androgen receptor (AR) can potentiate leptin-STAT3 signaling which is closely associated with energy expenditure. By extending this work, we identified a testosterone analogue, S42 as a new selective androgen receptor modulator (SARM) and found that S42 can dramatically reduce serum triglyceride level in male castrated SD rats. The significance of androgen in atherosclerosis is controversial. We revealed the anti- atherosclerotic effect of endogenous androgen in animal atherosclerotic model and clarified one mechanism related with the suppression of oxidized LDL receptor, LOX-1.
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Research Products
(44 results)
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[Journal Article] Serum gamma-glutamyltransferase, triglyceride and total cholesterol are possible prediabetic risk markers in young Japanese men.2010
Author(s)
Akehi Y, Mitsuyoshi Y, Tatsumoto A, Yoshida R, Ohkubo K, Kudo T, Ashida K, Anzai K, Yamashita T, Kawashima H, Ono J, Yanase T
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Journal Title
Endocrine J 57
Pages: 981-989
Peer Reviewed
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[Journal Article] A novel synthetic androgen receptor ligand, S42, works as a selective androgen receptor modulator and possesses metabolic effects with little impact on the prostate.2009
Author(s)
Min L, Yanase T, Tanaka T, Fan W, Nomura M, Kawate H, Okabe T, Takayanagi R, Nawata H
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Journal Title
Endocrinology 150
Pages: 5606-16
Peer Reviewed
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[Journal Article] Characterizaton of human growth differntiation factor-9 signaling in ovarian granulose cells.2008
Author(s)
Mottershead D.G, Pulkko M, Muggalla P, Pastemach A, Tolone M, Myllymaa S, Korchynskyi O, Nishi Y, Yanase T, Lun S, Juengel J, Laitinen M, Rivos O.
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Journal Title
Mol Cell Endocrinol 283
Pages: 58-67
Peer Reviewed
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[Journal Article] Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression.2008
Author(s)
Shirohzu H, Okabe T, Gondo S, Tanaka T, Ohe K, Morinaga H, Kawate H, Nomura M, Takayanagi R, Nawata H, Yanase T
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Journal Title
Biochem Biophys Res Commun 369
Pages: 862-867
Peer Reviewed
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[Journal Article] Working committee on clinical practice guidelines for late-onset hypogonadism ; Japanese Urological Association/Society for Study of Aging Male. Clinical practice manual for late-onset hypogonadism syndrome.2008
Author(s)
Namiki M, Akaza H, Shimazui T, Ito N, Iwamoto T, Baba K, Kumano H, Koh E, TsujimuraA, Matsumiya K, Horie S, Maruyama O, Marumo K, Yanase T, Kumamoto Y.
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Journal Title
Int J Urol 15
Pages: 377-388
Peer Reviewed
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