Investigation of the genes associated with bone mineral density by high-density SNP chip analysis in a large cohort study

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390264
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kyushu University
• Principal Investigator: TAKAYANAGI Ryoichi 九州大学, 大学院・医学研究院, 教授 (30154917)
• Co-Investigator(Renkei-kenkyūsha): OHNAKA Keizo 九州大学, 大学院・医学研究院, 講師 (30325518) ; YAMAMOTO Ken 九州大学, 生体防御医学研究所, 准教授 (60274528)
• Project Period (FY): 2008 – 2010
• Keywords: 骨密度 / 遺伝子多型 / 骨粗鬆症 / コホート

Research Abstract

To explore candidate g:enes associated with bone mineral density(BMD) of Japanese women, we performed a genome-wide association study(GWAS) in a large community-based cohort. The study subjects were postmenopausal women without taking any drugs, having any diseases or gynecological history. The GWAS and the following analyses uncovered several candidate genes to be associated with BMD in Japanese women.

Research Products

• [Journal Article] Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus (2011)
  • Author(s): Takayanagi R, Inoguchi T, Ohnaka K.
  • Journal Title: J Clin Biochem Nutr Volume: 48(1) Pages: 72-77
  • Peer Reviewed
• [Journal Article] Raloxifene induces nucleolar translocation of the estrogen receptor (2010)
  • Author(s): Gushima M, Kawate H, Ohnaka K, Nomura M, Takayanagi R.
  • Journal Title: Mol Cell Endocrinol Volume: 319(1-2) Pages: 14-22
  • Peer Reviewed
• [Journal Article] Alendronate improves QOL of postmenopausal women with osteoporosis (2010)
  • Author(s): Kawate H, Ohnaka K, Adachi M, Kono S, Ikematsu H, Matsuo H, Higuchi K, Takayama T, Takayanagi R.
  • Journal Title: Clin Interv Aging Volume: 5 Pages: 123-131
  • Peer Reviewed
• [Journal Article] Inverse associations of serum bilirubin with C-reactive protein, glycated he moglobin, and prevalence of diabetes mellitus in middle-aged and elderly Japanese men and women (2010)
  • Author(s): Ohnaka K, Kono S, Inoguchi T, Yin G, Morita M, Adachi M, Kawate H, Takayanagi R.
  • Journal Title: Diabetes Res Clin Pract Volume: 88(1) Pages: 103-110
  • Peer Reviewed
• [Journal Article] Blood pressure and hypertension are associated with 7 loci in the Japanese population (2010)
  • Author(s): Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N.
  • Journal Title: Circulation Volume: 121(21) Pages: 2302-2309
  • Peer Reviewed
• [Journal Article] Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women (2009)
  • Author(s): Ohnaka K, Yamamoto K, Nakamura K, Adachi M, Kawate H, Kono S, Takayanagi R.
  • Journal Title: Geriatr Gerontrol Int Volume: 9(3) Pages: 304-309
  • Peer Reviewed
• [Journal Article] 福岡骨粗鬆症コホート研究 (2009)
  • Author(s): 大中佳三日本人の骨密度関連遺伝子の網羅的解析
  • Journal Title: 日本老年医学会雑誌 Volume: 46(2) Pages: 114-116
  • Peer Reviewed
• [Journal Article] アンドロゲン、エストロゲンと骨代謝マーカー (2009)
  • Author(s): 大中佳三、高柳涼一
  • Journal Title: CLINICAL CALCIUM Volume: 19(8) Pages: 1118-1124
  • Peer Reviewed
• [Journal Article] 閉経後のステロイド性骨粗鬆症に対するラロキシフェンとビスフォスフォネートの臨床効果の比較 (2008)
  • Author(s): 高柳涼一、大中佳三
  • Journal Title: Osteoporosis Japan Volume: 16(4) Pages: 298-301
  • Peer Reviewed
• [Presentation] Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus (2011)
  • Author(s): Ryoichi Takayanagi, Toyoshi Inoguchi, Keizo Ohnaka
  • Organizer: International Symposium on Free Radical Research
  • Place of Presentation: Contribution to Medicine, Kyoto
  • Year and Date: 2011-01-22
• [Presentation] 九州大学福岡コホートの展望 (2011)
  • Author(s): 古野純典、高柳涼一、大中佳三
  • Organizer: 第21回日本疫学会学術集会
  • Year and Date: 2011-01-21
• [Presentation] シンポジウム「酸化ストレスと抗酸化システム」-「ビリルビンの抗酸化作用と生活習慣病」 (2009)
  • Author(s): 大中佳三
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2009-05-20
• [Presentation] Wntシグナル関連遺伝子の一塩基多型(SNPs)と骨密度の相関解析 (2008)
  • Author(s): 大中佳三、河手久弥、高柳涼一
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-29
• [Presentation] 日本人の骨密度関連遺伝子の網羅的解析(高密度SNP):福岡骨粗鬆症コホート研究 (2008)
  • Author(s): 大中佳三
  • Organizer: 第50回日本老年医学会学術総会-シンポジウム「骨粗鬆症と変形性関節症:研究と診療の最前線」
  • Place of Presentation: 千葉
  • Year and Date: 2008-06-21
• [Book] 副甲状腺疾患-新老年学第3版 (2010)
  • Author(s): 大中佳三
  • Total Pages: 1050-1059
  • Publisher: 東京大学出版会