2010 Fiscal Year Final Research Report
Roles of leukemogenic oncogenes in the regulation of metabolism, growth, and differentiation of hematopoietic stem cells
| Project/Area Number |
20390269
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUMURA Itaru Osaka University, 医学部, 教授 (00294083)
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| Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 大学院・医学系研究科, 教授 (20177489)
MIZUKI Masao 大阪大学, 附属病院, 准教授 (80283761)
ORITANI Kenji 大阪大学, 大学院・医学系研究科, 准教授 (70324762)
SHIBAYAMA Hirohiko 大阪大学, 大学院・医学系研究科, 講師 (60346202)
ASHIDA Takashi 近畿大学, 医学部附属病院, 准教授 (30211006)
TATSUMI Yoichi 近畿大学, 医学部附属病院, 准教授 (60236552)
SHIMADA Takahiro 近畿大学, 医学部, 講師 (90319674)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 造血幹細胞 / 遺伝子変異 / 慢性骨髄性白血病 / 活性型チロシンキナーゼ / 増殖シグナル |
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| Research Abstract |
1. The C-terminal deletion mutant of RUNX1, RUNX1dC, attenuates DNA-damage repair responses to UV irradiation in murine c-KIT^+Sca-1^+Lin^- cells by suppressing the expression of Gadd45a.
2. FIP1L1-PDGFRalpha not only enhanced the development of eosinophil progenitors (EoPs) from KSL cells but also aberrantly developed EoPs from progenitors in other lineages.
3.BCR-ABL inhibited erythropoiesis through the induction of p21^<WAF1> via Ras/MAPK, while it promoted granulopoiesis.
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