2010 Fiscal Year Final Research Report
Functional analysis of candidate responsible genes for 7q deletion in MDS/AML
| Project/Area Number |
20390271
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hiroshima University |
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Principal Investigator |
INABA Toshiya Hiroshima University, 原爆放射線医科学研究所, 教授 (60281292)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Hiroaki 広島大学, 原爆放射線医科学研究所, 教授 (40245064)
MATSUI Hirotaka 広島大学, 原爆放射線医科学研究所, 助教 (60379849)
ASOU Hiroya 広島大学, 原爆放射線医科学研究所, 准教授 (60243614)
AKI Daisuke 広島大学, 原爆放射線医科学研究所, 助教 (50420500)
MIYAZAKI Kazuko 広島大学, 原爆放射線医科学研究所, 助教 (00311811)
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| Project Period (FY) |
2008 – 2010
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| Keywords | MDS / 骨髄性白血病 / 7番染色体欠損 / 発がん抑制遺伝子 / 遺伝子欠損マウス / 分裂期異常 / エンドソーム代謝 |
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| Research Abstract |
We analyzed functions of candidate responsible genes for 7q- that is frequently observed in myeloid malignancies. Miki (LOC253012) promote prometaphase in mitosis, whereas Eff-1 (Samd9) and Eff-2 (Samd9L) facilitate fusion of endosomes resulting in promotion of ligand-bound ctokine receptors.
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[Journal Article] Upregulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17 ; 19)-positive leukemia cells.2010
Author(s)
Okuya M., Kurosawa H., Kikuchi J., Furukawa Y., Matsui H., Aki D., Matsunaga T., Inukai T., Goto H., Altura R.A., Sugita K., Arisaka O., Look A.T., Inaba T.
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Journal Title
J.Biol.Chem. 285
Pages: 1850-1860
Peer Reviewed
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[Journal Article] Identification of Zfp521/ZNF521 as acooperative gene for E2A-HLF to develop acute B-lineage leukemia.2010
Author(s)
Yamasaki N., Miyazaki K., Nagamachi A., Koller R., Oda H., Miyazaki M., Sasaki T., Honda Z, Wolff L., Inaba T., Honda H.
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Journal Title
Oncogene 29
Pages: 1963-1975
Peer Reviewed
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[Journal Article] Specific induction of CD33 expression by E2A-HLF : the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.2010
Author(s)
Akahane K., Inukai T., Inaba T., Kurosawa H., Look A.T., Kiyokawa N., Fujimoto J., Goto H., Endo M., Zhang X., Hirose K., Kuroda I., Honna H., Kagami J., Goi K., Nakazawa S., Sugita K.
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Journal Title
Leukemia 24
Pages: 865-869
Peer Reviewed
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[Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t (17;19).2010
Author(s)
Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H., Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H., Akahane K., Zhang X., Kuroda I., Honna H., Kagami K., Goi K., Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.
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Journal Title
Peer Reviewed
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[Journal Article] A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.2010
Author(s)
Nagamachi A., Htun P.W., Ma F., Miyazaki K., Yamasaki N., Kanno M., Inaba T., Honda Z.I., Okuda T., Oda H., Tsuji K., Honda H.
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Journal Title
Dev Biol. 345
Pages: 226-236
Peer Reviewed
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[Journal Article] Peptidoglycan and lipopolysaccharide activate PLCg2, leading to enhanced cytokine production in macrophages and endritic cells.2008
Author(s)
Aki D., Minoda Y., Yoshida H., Watanabe S., Yoshida R., Takaesu G., Chinen T., Inaba T., Hikida M., Kurosaki T., Saeki K., Yoshimura A.
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Journal Title
Genes Cells. 13
Pages: 199-208
Peer Reviewed
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[Journal Article] The Samd9L Gene : Transcriptional Regulation and Tissue-Specific Expression in Mouse Development.
Author(s)
Jiang, Q., Quaynor, B., Sun, A., Li, Q., Matsui, H., Honda, H., Inaba, T., Sprecher, E., Uitto J.
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Journal Title
J Invest Dermatol in press
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[Presentation] Level of sIL-2R depends on number of CD25 positive neoplastic cell and MMP-9 positive macrophage.2009
Author(s)
Yoshida, N., Sakai, A., Nitta, H., Okikawa, Y., Arihiro, K., Oda, M., Nishisaka, T., Fujiwara, M., Katayama, Y., Asaoku, H., Masunari, T., Matsui H., Kimura, A.
Organizer
第71回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2009-10-24
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[Presentation] Haploinsufficiency and deficiency of a 7q gene Titan (Samd9L) predispose leukemia development in cooperation with deregulated expression of a transcription factor, Evi1, or a histone demethylase, Fbxl10.2008
Author(s)
Nagamachi A., Asou H., Matsui H., Ozaki Y., Aki D., Miyazaki K., Yamasaki N., Miyazaki M., Wolff L, Koller R., Oda H, Inaba T., Honda H.
Organizer
The 50^<th> Annual Meeting of American Society of Hematology
Place of Presentation
San Francisco, CA.
Year and Date
2008-12-07
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