2010 Fiscal Year Final Research Report
Defense system by thrombin-HMGB1 axis
| Project/Area Number |
20390274
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kagoshima University |
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Principal Investigator |
MARUYAMA Ikuro Kagoshima University, 医歯学総合研究科, 特任教授 (20082282)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIGUCHI Teruto 鹿児島大学, 医歯学総合研究科, 准教授 (70250917)
KAWAHARA Koichi 鹿児島大学, 医歯学総合研究科, 助教 (10381170)
SHIMIZU Toshiaki 鹿児島大学, 医学部・歯学部附属病院, 医員 (50468055)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 循環器・高血圧 / 感染症 / 細胞・組織 |
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| Research Abstract |
An endothelial membrane protein, Thrombomodulin(TM) converts thrombin(T) from a procoagulant protease to an anticoagulant. We found that N-terminus of TM also can bind and neutralize death mediator HMGB1. T-TM complex degrades the HMGB1 bound to TM forming des-HMGB1. HMGB1 acts as triggering factor for hemostasis, innate immune and repair at injury sites. However systemic HMGB1 acts as a mediator for DIC, shock and MOF. Thus TM and HMGB1 is form a self-defense system.
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[Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice.2010
Author(s)
Matsuoka N, Itoh T, Watarai H, Sekine-Kondo E, Nagata N, Okamoto K, Mera T, Yamamoto H, Yamada S, Maruyama I, Taniguchi M, Yasunami Y.
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Journal Title
J Clin Invest. 120(3)
Pages: 735-743
Peer Reviewed
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[Journal Article] Hyperoxia suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats : laboratory study.2010
Author(s)
Fujita M, Tsuruta R, Kaneko T, Otsuka Y, Kutsuna S, Izumi T, Aoki T, Shitara M, Kasaoka S, Maruyama I, Yuasa M, Maekawa T.
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Journal Title
Shock. 34(3)
Pages: 299-305
Peer Reviewed
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[Journal Article] Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.2010
Author(s)
Suda K, Takeuchi H, Hagiwara T, Miyasho T, Okamoto M, Kawasako K, Yamada S, Suganuma K, Wada N, Saikawa Y, Fukunaga K, Funakoshi Y, Hashimoto S, Yokota H, Maruyama I, Ishizaka A, Kitagawa Y.
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Journal Title
Shock. 33(5)
Pages: 526-531
Peer Reviewed
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[Journal Article] Hyperglycemia enhances excessive superoxide anion radical generation, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats.2010
Author(s)
Tsuruta R, Fujita M, Ono T, Koda Y, Koga Y, Yamamoto T, Nanba M, Shitara M, Kasaoka S, Maruyama I, Yuasa M, Maekawa T.
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Journal Title
Brain Res. 1309
Pages: 155-163
Peer Reviewed
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[Journal Article] Xanthine oxidase is one of the major sources of superoxide anion radicals in blood after reperfusion in rats with forebrain ischemia/reperfusion.2009
Author(s)
Ono T, Tsuruta R, Fujita M, Aki HS, Kutsuna S, Kawamura Y, Wakatsuki J, Aoki T, Kobayashi C, Kasaoka S, Maruyama I, Yuasa M, Maekawa T.
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Journal Title
Brain Res. 1305
Pages: 158-167
Peer Reviewed
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[Journal Article] Elevation of jugular venous superoxide anion radical is associated with early inflammation, oxidative stress, and endothelial injury in forebrain ischemia-reperfusion rats.2009
Author(s)
Aki HS, Fujita M, Yamashita S, Fujimoto K, Kumagai K, Tsuruta R, Kasaoka S, Aoki T, Nanba M, Murata H, Yuasa M, Maruyama I, Maekawa T.
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Journal Title
Brain Res. 1292
Pages: 180-190
Peer Reviewed
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