Biologic significance of candidate genes in genomic alteration regions of lymphoidmalignancies

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390277
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: SETO Masao Aichi Cancer Center Research Institute, 遺伝子医療研究部, 部長 (80154665)
• Project Period (FY): 2008 – 2010
• Keywords: アレイCGH / 細胞増殖 / 細胞分化 / アポトーシス

Research Abstract

Ocular adnexal marginal zone B cell lymphoma (Ocular MALT lymphoma) has been shown to possess characteristic 6q23.3 loss and the candidate gene was found to be TNFAIP3/A20 by our group. The loss was also found in about 31% of mantle cell lymphoma and 50% of ABC type diffuse large B-cell lymphoma. The knock-down experiment revealed that the loss of the gene leads to activation of NF-kappaB. When the gene was knock-down in EB virus immortalized B-cell, the colony formation ability was increased, suggesting that the loss contribute B-cell lymphomagenesis.