2010 Fiscal Year Final Research Report
Studies on the role of annexin7 in the pathophysiology and therapies of rheumatoid arthritis using proteomics
| Project/Area Number |
20390283
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
KATO Tomohiro St.Marianna University School of Medicine, 医学部, 教授 (80233807)
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| Co-Investigator(Kenkyū-buntansha) |
YUDO Kazuo 聖マリアンナ医科大学, 医学(系)研究科(研究院), 教授 (60272928)
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| Project Period (FY) |
2008 – 2010
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| Keywords | プロテオミクス / アネキシン7 / 関節リウマチ / 翻訳後修飾 / 治療標的 |
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| Research Abstract |
Rheumatoid arthritis (RA) is a chronic inflammatory disease, involving multiple joints. In addition to the biologics, novel therapies should be established. We identified a novel RA-related protein of annexin 7 by proteomics, evidenced arthritogenecity of annexin7 and its role as a therapeutic target suing transgenic mice. Further, we evidenced annexin 7 contributed to arthritis through IL-8. Our study would be useful to establish a new therapy for RA.
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