2010 Fiscal Year Final Research Report
The role of MRI restricted T cells in arthritis
Project/Area Number |
20390284
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
MIYAKE Sachiko National Center of Neurology and Psychiatry, 神経研究所免疫研究部, 室長 (50266045)
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Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Daiju 独)国立精神・神経医療研究センター, 神経研究所免疫研究部, 研究員 (60462793)
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Co-Investigator(Renkei-kenkyūsha) |
ICHIKAWA Daiju 独)国立精神・神経医療研究センター, 神経研究所免疫研究部, 研究員 (60462793)
|
Project Period (FY) |
2008 – 2010
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Keywords | NKT細胞 / MR1 / 関節炎 / 免疫調節性細胞 / 腸内細菌叢 |
Research Abstract |
MHC-related molecule-1 (MR1)-restricted T cells are restricted by a nonpolymorphic MHC class 1b molecule, MR1, and express an invariant TCRα chain. MR1-restricted T cells are selected in the thymus in an MR1-dependent manner, but, interestingly, MR1-restricted T cells require B cells as well as commensal flora for their peripheral expansion. We demonstrated that MR1-restricted T cells contribute to the arthritis severity of CIA and CAIA, mostly by augmenting joint inflammation in the effector phase of arthritis. Furthermore, we showed that the frequency of MR1-restricted T cells in peripheral blood is reduced in patients with rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis.
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[Journal Article] Suppression of experimental autoimmune encephalomyelitis by Ghrelin2009
Author(s)
Theil MM, Miyake S, Mizuno M, Tomi C, Croxford J, Hosoda H, Theil J, von Horsten S, Yokote H, Chiba A, Lin Y, Oki S, Akamizu T, Kanagawa K, Yamamura T
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Journal Title
J Immunol 83(4)
Pages: 2859-66
Peer Reviewed
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[Presentation] Celecoxib analogue lacking COX-2 inhibitory activity inhibits arthritis by suppressing IL-23 and inflammatory cytokines2010
Author(s)
Chiba A, Ryohsuke T, Miho M, Tomi C, Ichikawa D, Iraide A, Yamamura T, Vandenbroeck K, Miyake S
Organizer
American College of Rheumatology 73^<th> Annual Scientific Meeting (Arthritis Rheum. 62:S371,2010)
Place of Presentation
Atlanta, Georgia
Year and Date
2010-11-07
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[Presentation] 新規celecoxibアナログはTh17,Th1細胞の抑制を介して多発性硬化症,関節リウマチのマウスモデルを抑制する2009
Author(s)
宮崎雄生,千葉麻子,水野美歩,任海千春,市川大樹,Iraide Alloza,山村隆,Koen Vandenbroeck,三宅幸子
Organizer
ワークショップ18,第39回日本免疫学会総会
Place of Presentation
大坂
Year and Date
2009-12-02
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