2010 Fiscal Year Final Research Report
Functional maturation of regulatory T cells during child growth and their disorders
| Project/Area Number |
20390294
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Toyama |
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Principal Investigator |
MIYAWAKI Toshio University of Toyama, 大学院・医学薬学研究部(医学), 教授 (10143885)
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| Co-Investigator(Kenkyū-buntansha) |
KANEGANE Hirokzu 富山大学, 大学病院, 講師 (00293324)
ADACHI Yuhichi 富山大学, 大学病院, 講師 (80184191)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 制御性T細胞 / FOXP3遺伝子 / IPEX / フローサイトメトリー / 遺伝子解析 / IL-7受容体 |
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| Research Abstract |
This study was intended to elucidate the functional maturation process of human regulatory T (Treg) cells through the pathogenic examination of congenital deficiency of Treg cells (IPEX). We developed the simple and easy method by flow cytometry for detection of IPEX patients, resulting in identification of some new IPEX cases in Japan. Based on the analyses of IPEX patients, the IPEX case undergoing bone marrow transplantation, carriers, newborns and healthy adults, it could partially be clarified that FOXP3, the product of the gene responsible for IPEX, plays a crucial role in development and differentiation of Treg cells in humans.
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[Presentation] T-B+NK+ severe combined immunodeficiency caused by a common gamma chain deficiency.2010
Author(s)
Kanegane H., Koura U., Sakaki H., Otsubo K., Nomura K., Morio T., Wada T., Yachie A., Oshima K., Ohara O., Miyawaki T.
Organizer
2010 First American Primary Immune Deficiency National Conference
Place of Presentation
Philadelphia, USA.
Year and Date
20100520-20100523
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[Presentation] A Japanese patients with X-linked agammaglobulinemia and deafness caused by contiguous X-chromosome deletion including the BTK, TIMM8A, TAF7L, and DRP2 genes.2008
Author(s)
Kanegene H., Yamada M., Zhao M., Futatani T., Oh-ishi T., Sakiyama Y., Ariga T., Miyawaki T.
Organizer
The 13th meeting of the European Society for Immunodeficiencies
Place of Presentation
Netherlands.
Year and Date
20081016-20081019
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