2011 Fiscal Year Final Research Report
Targeting Survivin as a novel therapeutic strategy for the hematological malignancies with activating mutations on Flt3 gene
| Project/Area Number |
20390298
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Shimane University |
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Principal Investigator |
FUKUDA Seiji 島根大学, 医学部, 准教授 (30273147)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 小児血液学 / 造血器腫瘍 / Flt3 / Survivin |
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| Research Abstract |
ITD-Flt3 mutations in AML are associated with extremely poor prognosis of the patients, indicating additional therapeutic strategies are warranted. In the present study, we identified that Survivin positively regulates progression of acute leukemia induced by ITD-Flt3 in mice model. While the data suggest that targeting Survivin can be a novel treatment strategy for ITD-Flt3+acute leukemia, we also found that antagonizing Survivin impairs normal hematopoietic stem cell(HSC) function. However, our data demonstrated that Evi-1 partially but significantly compensates impaired HSC function induced by loss of Survivin, suggesting that manipulation of Survivin/Evi-1 pathway may represent potential salvage strategy to protect HSC in the patients undergoing anti-Survivin therapies.
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Research Products
(23 results)
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[Journal Article] The Human Immunodeficiency Virus Protease Inhibitor Ritonavir Inhibits Lung Cancer Cells, in Part, by Inhibition of Survivin2011
Author(s)
Srirangam A, Milani M, Mitra R, Guo Z, Rodriguez M, Kathuria H, Fukuda S, Rizzardi A, Schmechel S, Skalnik DG, Pelus LM, Potter DA
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Journal Title
J Thorac Oncol
Volume: 6
Pages: 661-670
DOI
Peer Reviewed
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[Presentation] Survivin Modulates Gene Expression That Connects through An Extensive Functional Signaling Network and Regulates Proliferation of Hematopoietic Stem Cells through Evi-12010
Author(s)
Fukuda S., Sihgh P., Hoggatt J., Speth J., Abe M., Conway EM., Crispino J/. Nucifora G., Yamaguchi S., Pelus LM
Organizer
52^<nd> Annual meeting of the American Society of Hematology
Place of Presentation
Orlando, FL, USA
Year and Date
2010-10-06
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