2010 Fiscal Year Final Research Report
Molecular mechanisms of closure of the ductus arteriosus
| Project/Area Number |
20390300
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Waseda University |
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Principal Investigator |
MINAMISAWA Susumu Waseda University, 理工学術院, 教授 (40257332)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 発達小児科学 / 小児循環器学 / 骨格筋・平滑筋 / 未熟児・新生児医学 / 血管病態学 / 分子生理学 / 生理活性物質 |
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| Research Abstract |
The ductus arteriosus (DA), a fetal arterial connection between the main pulmonary artery and the descending aorta, normally closes immediately after birth. The DA is a normal and essential fetal structure. However, it becomes abnormal if it remains patent after birth. In addition to functional closure of the DA (vasoconstriction), anatomical closure of the DA is essential for the final DA closure. The present study identified that the DA-specific downstream signals via PGE2-EP4 stimulation induced vascular remodeling of the DA to promote anatomical closure. Furthermore, we found that other factors such as calcium influx via T-type calcium channels and growth hormone play a role in vascular remodeling in the DA. Clarifying the molecular mechanism of DA closure will lead to develop a novel therapeutic strategy for patent DA.
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[Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010
Author(s)
Yokoyama U, Minamisawa S (correspondence), Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y.
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Journal Title
Peer Reviewed
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[Journal Article] T channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation.2009
Author(s)
Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S (correspondence).
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Journal Title
J Biol Chem. 284(36)
Pages: 24025-34
Peer Reviewed
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[Journal Article] Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration.2008
Author(s)
Yokoyama U, induced closure(correspondence), Quan H, Akaike T, Jin M, Otsu K, Ulucan C, Wang X, Baljinnyam E, Takaoka M, Sata M, Ishikawa Y.
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Journal Title
Am J Physiol Heart Circ Physiol. 295(4)
Pages: H1547-55
Peer Reviewed
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[Journal Article] PGE2-activated Epac promotes neointimal cushion formation of the rat ductus arteriosus by a process distinct from that of PKA.2008
Author(s)
Yokoyama U, Minamisawa S (correspondence), Quan H, Akaike T, Suzuki S, Jin M, Jiao Q, Watanabe M, Otsu K, Iwasaki S, Nishimaki S, Sato M, Ishikawa Y.
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Journal Title
J Biol Chem. 1283(42)
Pages: 28702-9
Peer Reviewed
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[Presentation]2008
Author(s)
赤池徹, 他
Organizer
第85回日本生理学会大会
Place of Presentation
東京(ポスター発表)
Year and Date
20080300
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