2012 Fiscal Year Final Research Report
Proteomic analysis of constriction mechanisms in response to oxygen in the ductus arteriosus
| Project/Area Number |
20390303
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2012
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| Keywords | タンパク質 / シグナル伝達 / 動脈管 / 酸素感受性 / プロテオミクス |
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| Research Abstract |
Direct or indirect interaction of oxygen-sensing voltage-gated potassium channel 1.5 (Kv1.5) with Kvb1.2, α actinin-2, SAP97, valosin containing protein, clathrin, HSP60, ATP synthase F1 α/βsubunits, α-actinin, prohibitin-1/-2was detected. These proteins might have roles in the cellular transportation and regulation of Kv1.5. Gene expression related to the storage of Ca2+in the sarcoplasmic reticulum (SR) in ductus arteriosus (DA) and pulmonary artery (PA) varied depending on the vessels and fetal developmental stages. The SR activity in the DA might be specific depending on the developmental stage.
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