Brain substrates of and therapeutic approaches for motivational symptoms in schizophrenia and mood disorders : a near-infrared spectroscopy (NIRS) study

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390310
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: FUKUDA Masato Gunma University, 大学院・医学系研究科, 准教授 (20221533)
• Co-Investigator(Kenkyū-buntansha): MIKUNI Masahiko 群馬大学, 大学院・医学系研究科, 教授 (00125353) ; UEHARA Toru 群馬大学, 健康支援総合センター, 准教授 (60303145) ; KAMEYAMA Masaki 群馬大学, 大学院・医学系研究科, 助教 (00455982) ; YUUKI Naoya 群馬大学, 大学院・医学系研究科, 助教 (20420193) ; TAKAHASHI Keisuke 群馬大学, 医学部, 助教 (20455984)
• Project Period (FY): 2008 – 2010
• Keywords: 統合失調症 / 気分障害 / 意欲 / 近赤外線スペクトロスコピィ

Research Abstract

Brain substrates of motivational symptoms in psychiatric disorders were investigated using magnetic resonance imaging (MRI), near-infrared spectroscopy (NIRS), and magnetoencephalography (MEG). Prefrontal cortex volume and function correlated 1) with subjective sleepiness and fatigue, parental bonding in infancy, and cooperative personality in healthy subjects, 2) with global assessment of functioning (GAF), DNA polymorphism of sigma-1 receptor and catecholamine-O-methyl transferase (COMT) in schizophrenia, 3) with clinical symptoms in eating disorders, and 4) with mismatch negativity latency in bipolar disorder. These results suggest prefrontal cortex as brain substrates of motivational symptoms in psychiatric disorders.

Research Products

• [Journal Article] Total and regional brain volume reductions due to the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) : A voxel-based morphometric study. (2010)
  • Author(s): Ikeda Y, Kameyama M, Narita K, Takei Y, Suda M, Aoyama Y, Yuuki N, Sakurai N, Amanuma M, Fukuda M, Mikuni M
  • Journal Title: Prog Neuro Psychopharmacol Biol Psychiatry 34 Pages: 244-246
  • Peer Reviewed
• [Journal Article] Preattentive dysfunction in bipolar disorder : MEG study using auditory mismatch negativity. (2010)
  • Author(s): Takei Y, Kumano S, Maki Y, Hattori S, Kawakubo Y, Kasai K, Fukuda M, Mikuni M
  • Journal Title: Prog Neuro Psychopharmacol Biol Psychiatry 34 Pages: 903-912
  • Peer Reviewed
• [Journal Article] Relationship of parental bonding styles with gray matter volume of the dorsolateral prefrontal cortex in young adults. (2010)
  • Author(s): Narita K, Takei Y, Suda M, Aoyama Y, Uehara T, Kosaka H, Amanuma M, Fukuda M, Mikuni M
  • Journal Title: Prog Neuro Psychopharmacol Biol Psychiatry 34 Pages: 624-631
  • Peer Reviewed
• [Journal Article] Dieting tendency and eating behavior problems in eating disorder correlate with right frontotemporal and left orbitofrontal cortex : a near-infrared spectroscopy study. (2010)
  • Author(s): Suda M, Uehara T, Fukuda M, Sato T, Kameyama M, Mikuni M
  • Journal Title: J Psychiatr Res 44 Pages: 547-555
  • Peer Reviewed
• [Journal Article] Frontopolar activation during face-to-face conversation : an in situ study using near-infrared spectroscopy. (2010)
  • Author(s): Suda M, Takei Y, Aoyama Y, Narita K, Sato T, Fukuda M, Mikuni M
  • Journal Title: Neuropsyochologia 48 Pages: 441-447
  • Peer Reviewed
• [Journal Article] A case of lithium intoxication with periodic sharp waves. (2009)
  • Author(s): Suda M, Kubota F, Hiraoka T, Hattori S, Aihara Y, Fukuda M, Mikuni M
  • Journal Title: Pharmacopsychiatry 42 Pages: 122-123
  • Peer Reviewed
• [Journal Article] Association between catechol-O-methyltrasferase Va1108/158Met genotype and prefrontal hemodynamic response in schizophrenia (2009)
  • Author(s): Takizawa R, Tochigi M, Kawakubo Y, Marumo K, Sasaki T, Fukuda M, Kasai K
  • Journal Title: PLoS ONE 4 Pages: e5495
  • Peer Reviewed
• [Journal Article] Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia. (2009)
  • Author(s): Takizawa R, Hashimoto K, Tochigi M, Kawakubo Y, Marumo K, Sasaki T, Fukuda M, Kasai K
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 33 Pages: 491-8
  • Peer Reviewed
• [Journal Article] Risk of developing schizophrenia among Japanese high-risk offspring of affected parent : outcome of a twenty-four-year follow up. (2009)
  • Author(s): Nishida A, Sasaki T, Harada S, Fukuda M, Masui K, Nishimura Y, Ikebuchi E, Okazaki Y
  • Journal Title: Psychiat Clin Neurosci 63 Pages: 88-93
  • Peer Reviewed
• [Journal Article] Subjective feeling of psychological fatigue is related to decreased reactivity in ventrolateral prefrontal cortex. (2009)
  • Author(s): Suda M, Fukuda M, Sato T, Iwata S, Song M, Kameyama M, Mikuni M
  • Journal Title: Brain Res 1252 Pages: 152-160
  • Peer Reviewed
• [Journal Article] Stimulus intensity dependence of cerebral blood volume changes in left frontal lobe by low-frequency rTMS to right frontal lobe : a near-infrared spectroscopy study. (2009)
  • Author(s): Aoyama Y, Hanaoka N, Kameyama M, Suda M, Sato T, Song M, Fukuda M, Mikuni M
  • Journal Title: Neurosci Res 63 Pages: 47-51
  • Peer Reviewed
• [Journal Article] Preattentive dysfunction in major depression : magnetoencephalography study using auditory mismatch negativity. (2009)
  • Author(s): Takei Y, Kumano S, Hattori S, Uehara T, Kawakubo Y, Kasai K, Fukuda M, Mikuni M
  • Journal Title: Psychophysiology 46 Pages: 52-61
  • Peer Reviewed
• [Journal Article] The influence of gender and personality traits on individual difference in auditory mismatch : a magnetoencephalographic (MMNm) study. (2008)
  • Author(s): Matsubayashi J, Kawakubo Y, Suga M, Takei Y, Kumano S, Fukuda M, Ito K, Yumoto M, Kasai K
  • Journal Title: Brain Res 1236 Pages: 159-165
  • Peer Reviewed
• [Journal Article] Reduced frontopolar activation during verbal fluency task in schizophrenia : a multi-channel near-infrared spectroscopy study. (2008)
  • Author(s): Takizawa R, Kasai K, Kawakubo Y, Marumo M, Kawasaki S, Yamasue H, Fukuda M
  • Journal Title: Schizophr Res 99 Pages: 250-262
  • Peer Reviewed
• [Journal Article] Decreased cortical reactivity underlies subjective daytime light sleepiness in healthy subjects : a multichannel near-infrared spectroscopy study. (2008)
  • Author(s): Suda M, Sato T, Kameyama M, Ito M, Suto T, Yamagishi Y, Uehara T, Fukuda M, Mikuni M
  • Journal Title: Neurosci Res 60 Pages: 319-326
  • Peer Reviewed
• [Journal Article] Relationship between age at onset and magnetic resonance image (MRI)-defined hyperintensities in mood disorders. (2008)
  • Author(s): Takahashi K, Oshima A, Ida I, Kumano H, Yuuki N, Fukuda M, Amanuma A, Endo K, Mikuni M
  • Journal Title: J Psychiatr Res 42 Pages: 443-450
  • Peer Reviewed
• [Journal Article] Volume reduction of ventromedial prefrontal cortex in bipolar II patients with rapid cycling : a voxel-based morphometric study.
  • Author(s): Varita K, Suda M, Takei Y, Aoyama Y, Majima T, Kameyama M, Kosaka H, Amanuma M, Fukuda M, Mikuni M
  • Journal Title: Prog Neuro Psychopharmacol Biol Psychiatry. (in press)
  • Peer Reviewed
• [Presentation] Near-infrared spectroscopy in psychiatry (2010)
  • Author(s): Fukuda M, Suda M, Takei Y, Aoyama Y, Sato T, Sakurai N, Narita K, Kameyama M, Uehara T, Mikuni M
  • Organizer: (Symposium 2 : Use of near-infrared spectroscopy (NIRS)). The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20101028-20101101
• [Presentation] Near-infrared spectroscopy (NIRS) in psychiatric disorders (2010)
  • Author(s): Takizawa R, Kasai K, Fukuda M
  • Organizer: (Symposium 12 Physiological abnormalities in psychiatric disease). The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20101028-20101101
• [Presentation] Approval of MRS as the advanced medical technology in psychiatry (2010)
  • Author(s): Fukuda M, Suda M, Takei Y, Aoyama Y, Sato T, Sakurai N, Narita K, Kameyama M, Uehara T, Mikuni M
  • Organizer: (Symposium 52 : MRS application in clinical psychiatry). The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20101028-20101101
• [Presentation] MRS application to psychiatric diagnosis and clinical evaluation (2010)
  • Author(s): Takizawa R, Kasai K, Fukuda M
  • Organizer: (Symposium 52 : NIRS application in clinical psychiatry). The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20101028-20101101
• [Presentation] Near-infrared spectroscopy in mood disorders (2009)
  • Author(s): Fukuda M, Suda M, Aoyama Y, Takei Y, Sato T, Kameyama M, Narita K, Uehara T, Mikuni M
  • Organizer: (Symposium S-05 : Near-infrared spectroscopy in psychiatry : current status and future prospect). The 9th World Congress of Biological Psychiatry
  • Place of Presentation: Paris, France
  • Year and Date: 20090628-20090702
• [Presentation] Frontal lobe function in eating disorders : a multichannel near-infrared spectroscopy study. (2008)
  • Author(s): Suda M, Fukuda M, Uehara T, Sato T, Aoyama Y, Mikuni M
  • Organizer: 13th Pacific Rim College of Psychiatrists Scientific Meeting
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20081030-20081102
• [Presentation] Frontal lobe dysfunction in schizophrenia : a near-infrared spectroscopy study (2008)
  • Author(s): Kameyama M, Fukuda M, Uehara T, Ida I, Mikuni M
  • Organizer: (Symposium 21 : Cognitive impairment in schizophrenia : neurobiology and therapeutic intervention). 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
  • Place of Presentation: Toyama, Japan
  • Year and Date: 20080911-20080913
• [Presentation] Effect of sigma-1 receptor gene polymorphism on prefrontal function in schizophrenia : a NIRS study. (2008)
  • Author(s): Takizawa R, Tochigi M, Kawakubo Y, Marumo K, Sasaki T, Fukuda M, Hashimoto K, Kasai K
  • Organizer: 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
  • Place of Presentation: Toyama, Japan
  • Year and Date: 20080911-20080913
• [Presentation] Future prospect of diagnosis and treatment of psychiatry disorders using near-infrared spectroscopy (2008)
  • Author(s): Fukuda M, Mikuni M
  • Organizer: (Symposium S-14. Monitoring pharmacotherapy in psychiatric disorders : functional neuroimaging and neurophysiological perspectives), The XXVI Collegium Internationale Neuro-Psychopharmacologium
  • Place of Presentation: Munich, Germany
  • Year and Date: 20080713-20080717
• [Presentation] Frontal lobe function in eating disorders : a multichannel near-infrared spectroscopy study. (2008)
  • Author(s): Suda M, Fukuda M, Sato T, Kameyama M,Mikuni M
  • Organizer: The XXVI Collegium Internationale Neuro-Psychopharmacologium
  • Place of Presentation: Munich, Germany
  • Year and Date: 20080713-20080717
• [Book] NIRS波形の臨床判読-先進医療「うつ症状の光トポグラフィー検査」ガイドブック (2011)
  • Author(s): 福田正人監修
  • Publisher: 中山書店
• [Book] 前頭葉でわかる精神疾患の臨床 (2010)
  • Author(s): 福田正人,鹿島晴雄編
  • Publisher: 中山書店
• [Book] 精神疾患とNIR-光トポグラフィー検査による脳機能イメージング (2009)
  • Author(s): 福田正人編
  • Publisher: 中山書店
• [Book] もう少し知りたい統合失調症の薬と脳 (2008)
  • Author(s): 福田正人編著
  • Publisher: 日本評論社
• [Book] 精神疾患と脳画像(専門医のための精神科臨床リュミエール) (2008)
  • Author(s): 福田正人編著
  • Publisher: 中山書店