2010 Fiscal Year Final Research Report

The schizophrenia study about systems of dopamine, glutamate, and GABA by imaging mass spectrometry

Research Project

Project/Area Number	20390315
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	Fukushima Medical University
Principal Investigator	NIWA Shin-ichi Fukushima Medical University, 医学部, 教授 (30110703)
Project Period (FY)	2008 – 2010
Keywords	統合失調症 / 死後脳 / 質量顕微鏡 / ドパミン / グルタミン酸 / GABA / プロテオーム解析
Research Abstract	There are limits to brain research on psychiatric disorders using animals. In the present study, we analyzed postmortem brain samples of schizophrenia patients obtained from the Postmortem Brain Bank of Fukushima using a cutting-edge technology called mass microscopy. While dopamine, glutamic acid, and GABA are thought to play key roles in the etiology of schizophrenia, and neural networks are considered to form the basis of neurotransmission, in the present study, we succeeded in visualizing the 2-dimensional distribution of neuronal membrane components that are important for elucidating neural networks in the postmortem brains of schizophrenia patients.

(3 results)