2011 Fiscal Year Final Research Report
Translational research for establishment of heavy ion radiotherapy for cancer
| Project/Area Number |
20390324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
NAKANO Takashi 群馬大学, 大学院・医学系研究科, 教授 (20211427)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Hideyuki 筑波大学, 人間総合科学研究科, 教授 (50235222)
TAKAHASHI Takeo 埼玉医科大学, 医学部, 教授 (70241883)
SUZUKI Yoshiyuki 群馬大学, 大学院・医学系研究科, 准教授 (60334116)
ISHIKAWA Hitoshi 筑波大学, 人間総合科学研究科, 准教授 (70344918)
ISHIUCHI Shogo 琉球大学, 医学部, 教授 (10312878)
OHNO Tatsuya 群馬大学, 重粒子線医学研究センター, 教授 (10344061)
YAMAGUCHI Mitsutaka 日本原子力研究開発機構, 研究員 (10375404)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 重粒子線 / 放射線治療 / 放射線生物学 / 粒子線治療 / 放射線腫瘍学 |
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| Research Abstract |
1) Carbon-ion beams were about 10-fold more effective than X-rays in immature hippocampal neurons. X-irradiation immediately induced morphological changes in axons and dendrite. These changes seemed to be caused by x-irradiation evoking depolymerization of microfilament. 2) Under severe hypoxic condition for 1 hour, oxygen enhancement ratio (OER) of X-ray was calculated as 2.7. Under severe hypoxic condition for 24 hour, OER of X-ray was decreased from 2.6 to 1.1 by addition of mTOR inhibitor but, OER was not changed in carbon-ion beam irradiation. 3) The RBE of C-beams to X-rays in the normal cerebellum of infant rats with rat organotypic slice culture system was assumed to be 1.4.4) Radiation-induced ICAM-1 expression on HUVE cells was regulated by TGF-β1 and carbon-beam induced higher ICAM-1 expression than X-ray. 5) HIF-1α expression was a prognostic factor in patients with locally advanced rectal cancer. 6) The cost-effectiveness of carbon beam therapy was good for advanced rectal cancers and lung cancers by analyzing clinical data.
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[Journal Article] The radiobiological effectiveness of carbon-ion beams on growing neurons2009
Author(s)
Al-Jahdari WS, Suzuki Y, Yoshida Y, Hamada N, Shirai K, Noda SE, Funayama T, Sakashita T, Kobayashi Y, Saito S, Goto F, Nakano T
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Journal Title
Int J Radiat Biol
Volume: 85
Pages: 9-700
Peer Reviewed
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[Journal Article] Adverse effects of androgen deprivation therapy on persistent genitourinary complications after carbon ion radiotherapy for prostate cancer2008
Author(s)
Ishikawa H, Tsuji H, Kamada T, Hirasawa N, Yanagi T, Mizoe JE, Akakura K, Suzuki H, Shimazaki J, Nakano T, Tsujii H
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 72(1)
Pages: 78-84
Peer Reviewed
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