Organization of PET brain bank

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390334
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Metropolitan Institute of Gerontology
• Principal Investigator: ISHIWATA Kiichi Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究部長 (50143037)
• Co-Investigator(Kenkyū-buntansha): NARIAI Tadashi 東京医科歯科大学, 医学部付属病院, 講師 (00228090) ; MISHINA Masahiro 日本医科大学, 医学部, 助教 (70322518)
• Co-Investigator(Renkei-kenkyūsha): ISHII Kenji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (10231135) ; ODA Keiichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (70224235) ; SAKATA Muneyuki 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (00403329) ; TOYOHARA Jun 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50425659) ; KIMURA Yuichi 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (60205002)
• Project Period (FY): 2008 – 2010
• Keywords: ポジトロンCT / 核医学 / 脳神経疾患

Research Abstract

To encourage PET pathophysiological studies and diagnosis of brain functions and brain disorders in Japan, practical and reliable database of many PET probes which evaluate the basic brain function such as blood flow and glucose metabolism and the neural transmission system was built. The database covers normal subjects including elderly and patients with brain disorders for several probes. Methodological improvement of PET measurement and data analysis with PET-MRI fusion was also performed.

Research Products

• [Journal Article] Binding of pramipexole to extrastriatal dopamine D_2/D_3 receptors in the human brain : A positron emission tomography study using 11^C-FLB 457. (2011)
  • Author(s): Ishibashi K, Ishii K, Oda K, Mizusawa H, Ishiwata K.
  • Journal Title: PLoS ONE 6(3) Pages: e17723
• [Journal Article] Adenosine A2A receptors measured with [11C]TMSX PET in the striata of Parkinson's disease patients. (2011)
  • Author(s): Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii K.
  • Journal Title: PLoS ONE 6(2) Pages: e17338
• [Journal Article] Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson's disease. (2010)
  • Author(s): Ishibashi K, Kanemaru K, Saito Y, Murayama S, Oda K, Ishiwata K, Mizusawa H, Ishii K.
  • Journal Title: Acta Neurol Scand 122 Pages: 46-51
• [Journal Article] Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease. (2010)
  • Author(s): Ishibashi K, Ishii K, Oda K, Mizusawa H, Ishiwata K.
  • Journal Title: Nucl Med Commun 31(2) Pages: 159-166
• [Journal Article] Imaging of sigma_1 receptors in the human brain using PET and [11C]SA4503. (2009)
  • Author(s): Toyohara J, Sakata M, Ishiwata K.
  • Journal Title: CNS Agents Med Chem 9 Pages: 190-196
• [Journal Article] Adenosine receptor ligands and PET imaging of the CNS. In : Adenosine receptors in health and disease. (2009)
  • Author(s): Bauer A, Ishiwata K.
  • Journal Title: Handb Exp Pharmacol 193 Pages: 617-642
• [Presentation] [11^C]PIB脳内集積と髄液バイオマーカAβ1-42の関係 (2010)
  • Author(s): 石井賢二、金丸和富、滝本美咲、坂田宗之、織田圭一、豊原潤、村山繁雄、石渡喜二
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮市
  • Year and Date: 20101111-20101113
• [Presentation] Aging effect on adenosine A_1 receptors in human putamen-A MPDX PET study-. (2010)
  • Author(s): 石川雅智, 木村裕一, 石井賢二, 坂田宗之, 織田圭一, 小林士郎, 片山泰朗, 石渡喜一
  • Organizer: 16th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Barcelona
  • Year and Date: 20100606-20100610
• [Presentation] 11^C-FLB 457 PETによるpramipexole の線条体外D2受容体作用部位の検討 (2010)
  • Author(s): 石橋賢士、織田圭一、石渡喜一、水澤英洋、石井賢二
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100520-20100522
• [Presentation] アミロイドイメージングにおける視野外放射能の影響 (2010)
  • Author(s): 織田圭一、石井賢二、坂田宗之、石渡喜一
  • Organizer: 脳PETワークショップ
  • Place of Presentation: 横浜市
  • Year and Date: 2010-04-09
• [Presentation] 線条体ドパミントランスポータとドパミンD2受容体分布のパーキンソン病の病期による違い (2009)
  • Author(s): 三品雅洋、鈴木正彦、石井賢二、石渡喜一、北村伸、石橋賢士、織田圭一、坂田宗之、濱本真、小林士郎、片山泰朗
  • Organizer: 第21回日本脳循環代謝学会
  • Place of Presentation: 豊中市
  • Year and Date: 20091119-20091120
• [Presentation] 3D-PETにおける体幹部用シールドの効果-ファントム実験による検討 (2009)
  • Author(s): 織田圭一、坂田宗之、石井賢二、長縄美香、木村裕一、石渡喜一
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川市
  • Year and Date: 20091001-20091003
• [Presentation] Differential effect of APOE 4 alle on amyloid beta accumulation in AD and non-AD. (2009)
  • Author(s): Ishii K, Ishiwata K, Oda K, Sakata M, Ishikawa M, Ishibashi K, Saito Y, Tokumaru A, Kanemaru K, Murayama S
  • Organizer: Alzheimer's Association 2009 International Conference on Alzheimer's Disease
  • Place of Presentation: Vienna
  • Year and Date: 20090712-20090716
• [Presentation] Simplified quantitation of adenosine A_1 receptors with [^11C]MPDX PET and graphical analysis. (2009)
  • Author(s): Kimura Y, Naganawa M, Mishina M, Sakata M, Oda K, Ishii K, Ishiwata K
  • Organizer: BrainPET '09
  • Place of Presentation: Chicago
  • Year and Date: 20090629-20090703
• [Presentation] Simplified quantitation of adenosine A_2A receptor with [11^C]TMSX PET and graphical analysis. (2009)
  • Author(s): Naganawa M, Mishina M, Sakata M, Oda K, Ishii K, Ishiwata K, Kimura Y
  • Organizer: BrainPET '09
  • Place of Presentation: Chicago
  • Year and Date: 20090629-20090703
• [Presentation] アルツハイマー病における[11^C]PIB集積の意義-代謝低下・萎縮・罹病期間との相関 (2008)
  • Author(s): 石井賢二、織田圭一、川崎敬一、木村裕一、坂田宗之、石川雅智、石橋賢士、金丸和富、村山繁雄、石渡喜一
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 20081024-20081026
• [Presentation] ヒストグラム解析を用いたFDG-PET脳画像の評価 (2008)
  • Author(s): 川崎敬一、石井賢二、坂田宗之、織田圭一、石渡喜一
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 20081024-20081026
• [Presentation] 健常成人におけるApoE遺伝型と脳糖代謝画像の異常出現率との関連について (2008)
  • Author(s): 呉勁、川崎敬一、織田圭一、坂田宗之、石川雅智、橋本謙二、石渡喜一、石井賢二
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 20081024-20081026
• [Presentation] 同一ファントムを用いたFDG脳PET検査の3次元収集の施設間差の検討 (2008)
  • Author(s): 袴田大介、織田圭一、福士政広
  • Organizer: 第36回日本放射線技術学会秋季学術大会
  • Place of Presentation: 軽井沢
  • Year and Date: 20081023-20081025
• [Presentation] Does amyloid β accumulation modifiy clinical feature of frontotemporal dementia? (2008)
  • Author(s): Ishii K, Ishiwata K, Oda K, Kimura Y, Sakata M, Kawasaki K, Hashimoto M, Ishikawa M, Ishibashi K, Nishina Y, Saito Y, Tokumaru A, Kanemaru K, Murayama S
  • Organizer: International Conference on Alzhiemer's Disease
  • Place of Presentation: Chicago, USA
  • Year and Date: 20080726-20080731
• [Presentation] Variations in adenosine A_2A receptors following anti-parkinsonian therapy in drug naive Parkinson's disease using 11^C-TMSX PET. (2008)
  • Author(s): Mishina M, Ishii K, Kitamura S, Kimura Y, Naganawa M, Hashimoto M, Suzuki M, Oda K, Hamamoto M, Kobayashi S, Katayama Y, Ishiwata K
  • Organizer: The Movement Disorder Society's 12th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Chicago, USA
  • Year and Date: 20080622-20080626
• [Presentation] Regional Increase of the adenosine A_1 receptor binding in patients with intractable temporal lobe epilepsy. -A positron emission tomography study-. Annual Meeting of the Organization for Human Brain Mapping (2008)
  • Author(s): Nariai T, Ishiwata K, Kimura Y, Ishii K, Hosoda C, Inaji M, Maehara T, Ohno K
  • Organizer: Melbourne
  • Place of Presentation: Australia
  • Year and Date: 20080615-20080619
• [Book] Sauerwein W, et al.eds.Springer-Verlag, Wien.
  • Author(s): Nariai T, Ishiwata K.
  • Publisher: Analysis and Imaging. PET. In : Textbook of Neutron Capture Therapy.(in press)