2010 Fiscal Year Final Research Report
Novel Tumor Seeking PET Imaging focused on Epigenetic Regulation by Histone Deacetylases
| Project/Area Number |
20390335
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Miyazaki (2010)
Research Institute, Shiga Medical Center (2008-2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHI Tatsuya 滋賀県立成人病センター, 研究所, 総括研究員 (50324629)
KAGAWA Shinya 滋賀県立成人病センター, 研究所, 主任研究員 (10393191)
KAWAI Keiichi 金沢大学, 大学院・医学研究科, 教授 (30204663)
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| Co-Investigator(Renkei-kenkyūsha) |
ONOE Hirotata 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, チームリーダー (80214196)
MIZUMA Hiroshi 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 研究員 (00382200)
NAGAMACHI Shigeki 宮崎大学, 医学部, 准教授 (40180517)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ヒストン脱アセチル化酵素 / PET画像診断 / 癌 / 分子標的 |
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| Research Abstract |
Epigenetic modifications mediated by histone deacetylases(HDACs) play important roles in the mechanisms of different neurologic diseases and HDAC inhibitors(HDACIs) have shown promise in therapy. However, pharmacodynamic profiles of many HDACIs in the tumor remain largely unknown due to the lack of validated methods for noninvasive imaging of HDACs expression-activity. In this study, we have developed a novel PET imaging [^18F] FAHA.
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[Journal Article] Pharmacokinetics, metabolism, biodistribution, radiation dosimetry, and toxicology of (18) F-fluoroacetate((18) F-FACE) in non-human primates2012
Author(s)
Nishii R, Tong W, Wendt R 3rd, Soghomonyan S, Mukhopadhyay U, Balatoni J, Mawlawi O, Bidaut L, Tinkey P, Borne A, Alauddin M, Gonzalez-Lepera C, Yang B, Gelovani JG
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Journal Title
Mol Imaging Biol
Volume: 14
Pages: 213-224
Peer Reviewed
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[Journal Article] Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-acetate PET2012
Author(s)
Kobayashi M, Mori T, Kiyono Y, Tsujikawa T, Maruyama R, Higaki Y, Shikano N, Nishii R, Kawai K, Kudo T, Okazawa H
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Journal Title
Nucl Med Commun
Volume: 33
Pages: 130-138
Peer Reviewed
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[Journal Article] Putative transport mechanism and intracellular fate of trans-1-amino-3-^18F-fluorocyclobutanecarboxylic acid in human prostate cancer2012
Author(s)
Okudaira H, Shikano N, Nishii R, Miyagi T, Yoshimoto M, Kobayashi M, Ohe K, Nakanishi T, Tamai I, Namiki M, Kawai K
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Journal Title
J Nucl Med
Volume: 52
Pages: 822-829
Peer Reviewed
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[Journal Article] Comparison of the transcellular transport of FDG and D-glucose by the kidney epithelial cell line2011
Author(s)
Kobayashi M, Shikano N, Nishii R, Kiyono Y, Araki H, Nishi K, Oh M, Okudaira H, Ogura M, Yoshimoto M, Okazawa H, Fujibayashi Y, Kawai K
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Journal Title
LLC-PK1 Nucl Med Commun
Volume: 31
Pages: 141-146
Peer Reviewed
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[Presentation] Cell Uptake Study of [^18F] Fluoroacetate in Human-Derived Hepatocellular Carcinomas2011
Author(s)
Kenji Takemoto, Ryuichi Nishii, Etsuro Hatano, Shinya Kagawa, Tatsuya Higashi, Kan Toriguchi, Kazutaka Tanabe, KojiroTaura, Hiroshi Mizuma, Hirotaka Onoe, Shigeki Nagamachi, Shozo Tamura
Organizer
2011 World Molecular Imaging Congress
Place of Presentation
Sandiego, USA
Year and Date
20110907-10
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[Presentation] Preclinical assessment of [^18F]-FAHA PET imaging as a novel biomarker for HDAC activity2010
Author(s)
R. Nishii, H. Yeh, U. Mukhopadhyay, S. Soghomonyan, J. Balatoni, O. Mawlawi, M. M. Alauddin, T. Hisgashi, W. Tong, and J. G. Gelovani
Organizer
The 57th SNM Annual Meeting
Place of Presentation
Salt Lake City, USA
Year and Date
20100604-08
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