Functional Nanoparticles which Release Anticancer Agent by Applying a Magnetic Field

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390338
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Akita University
• Principal Investigator: MINAMIYA Yoshihiro Akita University, 大学院・医学系研究科, 准教授 (30239321)
• Co-Investigator(Kenkyū-buntansha): OGAWA Junichi 秋田大学, 大学院・医学系研究科, 教授 (20112774) ; SAITO Hajime 秋田大学, 医学部, 講師 (20323149) ; SAWADA Kenichi 秋田大学, 大学院・医学系研究科, 教授 (90226069)
• Co-Investigator(Renkei-kenkyūsha): KAWAGUCHI Haruma 慶應義塾大学, 理工学部, 教授 (30051808) ; UEDA Tomoaki 東京工業大学, 統合研究院, 教授 (50456258)
• Research Collaborator: II Tomoaki 慶應義塾大学, 理工学部・川口研究室, 学生 ; KOMORI Chiyo 秋田大学, 医学部附属病院・薬剤部, 研究員
• Project Period (FY): 2008 – 2010
• Keywords: ナノテクノロジー / 抗がん剤 / 機能性微粒子 / 癌 / 磁性体 / 高分子化合物

Research Abstract

We developed functional nanoparticles, combined with thermo-sensitive polymers and magnetite. The functional nanoparticles emit heat when exposed to an AC magnetic field, causing them to release drugs. We have utilized these functional nanoparticles to administer methotrexate, an anti-cancer agent, making them ideal candidates for cancer thermo-chemotherapy.