2010 Fiscal Year Final Research Report
Application of microRNA profilling to breast cancer diagnosis and therapy
| Project/Area Number |
20390342
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SHIMIZU Kazuharu Kyoto University, 薬学研究科, 教授 (50456836)
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| Co-Investigator(Kenkyū-buntansha) |
TOI Masakazu 京都大学, 医学研究科, 教授 (10207516)
TSUJIMOTO Gozoh 京都大学, 薬学研究科, 教授 (80172013)
SATO Fumikai 京都大学, 薬学研究科, 准教授 (20467426)
UENO Takayuki 京都大学, 医学研究科, 助教 (40452362)
TSUCHIYA Soken 京都大学, 薬学研究科, 助教 (80423002)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 乳癌 / マイクロRNA / マイクロアレイ |
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| Research Abstract |
In this project, we performed microRNA profiling for future application to breast cancer diagnosis and therapy. First, we identified miR-26a/30b as microRNAs involved in molecular mechanisms of trastuzumab therapy for HER2-positive breast cancer. Mir-26a/30b inhibited cell growth of breast cancer cells by targeting CCNE2. Secondary, we demonstrated that epigenetical regulation of miR200b cluster is associated with epithelial-mesenchymal transition of breast cancer cells. The miR200b cluster members inhibit cell motility by targeting fibronectin.
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