2010 Fiscal Year Final Research Report
Enhanced Angiogenic Potential of Bone Marrow Cells by Hypoxic Preconditioning
| Project/Area Number |
20390345
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
FURUTANI Akira Yamaguchi University, 医学部・附属病院, 学術研究員 (90346552)
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| Co-Investigator(Kenkyū-buntansha) |
HAMANO Kimikazu 山口大学, 大学院・医学系研究科, 教授 (60263787)
KUBO Masayuki 山口大学, 大学院・医学系研究科, 助教 (60420519)
LI Taoーsheng 山口大学, 大学院・医学系研究科, 講師 (50379997)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 骨髄細胞 / 血管再生 / 低酸素 / プレコンディショニング / 再生医療 / 虚血性疾患 / 加齢 / 糖尿病 |
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| Research Abstract |
Previous studies have demonstrated that hypoxic preconditioning of bone marrow cells can enhance their potency for inducing therapeutic angiogenesis. However, the exact mechanism of hypoxic preconditioning is not fully understood. Furthermore, experiments have used cells from young healthy individuals. This study shows that hypoxic preconditioning increases the retention of bone marrow cells after implantation into ischemic tissue, and that it also enhances the angiogenic potential of the cells with aged or diabetes-related functional impairment.
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