2010 Fiscal Year Final Research Report
Isolation and regulation of organ specific cancer stem cell
| Project/Area Number |
20390346
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKAMURA Masafumi Kyushu University, 大学病院, 講師 (30372741)
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| Co-Investigator(Kenkyū-buntansha) |
KATANO Mistuo 九州大学, 医学研究院, 教授 (10145203)
AKASHI Kouichi 九州大学, 医学研究院, 教授 (80380385)
NOMURA Masatoshi 九州大学, 大学病院, 講師 (30315080)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 実験外科学 |
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| Research Abstract |
Cancer stem cell (CSC) population was isolated in breast cancer cells. The population was confirmed to have the ability as CSC, which consisted of pluripotency, multi-drag resistance and tumorgenesis. Hedgehog (Hh) signal was found to be essential for maintenance and growth of CSC population. These data suggested that Hh signal is a good target of anti-CSCl therapy.
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